1616392-89-2

Upstream product

• 64495-55-2 6-nitro-1,2-dihydroquinolin-2-one 
• 296759-30-3 3-bromo-6-nitro-1,2-dihydroquinolin-2-one 
• 824-94-2 p-methoxybenzyl chloride 
• 59-31-4 2-quinolone 

Downstream Products

• 1616393-01-1 3-bromo-1-(4-methoxybenzyl)-6-(3-methoxyphenyl)quinolin-2(1H)-one 
• 1627095-03-7 3,6-diethoxy-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-91-6 6-amino-3-bromo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-93-8 1-(3-bromo-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-6-yl)urea 
• 1616392-95-0 N-(3-bromo-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-6-yl)acetamide 
• 1616392-97-2 3-bromo-6-iodo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616392-99-4 3-bromo-6-cyano-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616393-03-3 3-bromo-6-ethoxy-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1627095-04-8 3-ethoxy-6-iodo-1-(4-methoxybenzyl)quinolin-2(1H)-one 
• 1616393-08-8 N-(3-((1-(4-methoxybenzyl)-2-oxo-6-ureido-1,2-dihydroquinolin-3-yl)amino)phenyl)pyrrolidine-1-carboxamide 
• 1616393-10-2 N-(3-((1-(4-methoxybenzyl)-2-oxo-6-ureido-1,2-dihydroquinolin-3-yl)amino)-5-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)phenyl)pyrrolidine-1-carboxamide 
• 1616393-12-4 1-(1-(4-methoxybenzyl)-2-oxo-3-(phenylamino)-1,2-dihydroquinolin-6-yl)urea 
• 1616393-14-6 N-(3-((6-acetamido-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-3-yl)amino)phenyl)pyrrolidine-1-carboxamide 
• 1616393-16-8 N-(3-((6-cyano-1-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinolin-3-yl)amino)phenyl)pyrrolidine-1-carboxamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H) -ones as PDK1 inhibitors

PDK1 is an important regulator of the PI3K/Akt pathway, which has been found frequently activated in a large number of human cancers. Herein we described the preparation of novel substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors. The synthesis