1616470-04-2Relevant articles and documents
Total syntheses and in vivo quantitation of novel neurofuran and dihomo-isofuran derived from docosahexaenoic acid and adrenic acid
De La Torre, Aurlien,Lee, Yiu Yiu,Mazzoni, Attilio,Guy, Alexandre,Bultel-Ponc, Valrie,Durand, Thierry,Oger, Camille,Lee, Jetty Chung-Yung,Galano, Jean-Marie
, p. 2442 - 2446 (2015)
Neurofurans (NeuroFs) and dihomo-isofurans (dihomo-IsoFs) are produced in vivo by non-enzymatic free-radical pathways from docosahexaenoic and adrenic acids, respectively. As these metabolites are produced in minute amounts, their analyses in biological samples remain challenging. Syntheses of neurofuran and dihomo-isofurans described are based on a pivotal strategy, thanks to an enantiomerically enriched intermediate, which allowed, for the first time, access to both families: the alkenyl and enediol. Owing to this formation, quantitation of specific NeuroF and dihomo-IsoFs in biological samples was attainable.
Synthesis, discovery, and quantitation of dihomo-isofurans: Biomarkers for in vivo adrenic acid peroxidation
De La Torre, Aurelien,Lee, Yiu Yiu,Oger, Camille,Sangild, Per Torp,Durand, Thierry,Lee, Jetty Chung-Yung,Galano, Jean-Marie
supporting information, p. 6249 - 6252 (2014/06/23)
The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matte