1616594-57-0

Basic information

• Product Name: 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile
• CAS NO: 1616594-57-0
• Molecular Weight: 487.537
• Mol File: 1616594-57-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile(1616594-57-0)
• EPA Substance Registry System: 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile(1616594-57-0)

Safety Data

• Hazardous Substances Data: 1616594-57-0(Hazardous Substances Data)

Upstream product

• 1255207-47-6 3-bromo-6-fluoro-2-methyl-benzonitrile 
• 198633-76-0 2-fluoro-6-methyl-benzonitrile 
• 1255207-48-7 3-ethenyl-6-fluoro-2-methylbenzonitrile 
• 1255207-46-5 6-fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile 
• 1426071-25-1 tert-butyl (3S)-4-[2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 
• 1426072-82-3 tert-butyl (3R,9aS)-3-(3-cyano-4-fluoro-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 
• 883502-14-5 1-fluoro-2-iodo-3-methylbenzene 
• 1426073-08-6 3-(2-bromo-acetyl)-6-fluoro-2-methyl-benzonitrile 
• 1426073-09-7 (3R,9aS)-3-(3-cyano-4-fluoro-2-methyl-phenyl)-3-hydroxy-hexahydro-pyrazino[2,1-c][ 1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 1374573-47-3 5-(1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carboxylic acid 
• 59856-06-3 5-acetamidoindane 
• 24425-40-9 indan-5-amine 
• 58161-35-6 5-acetamido-1-indanone 
• 272104-21-9 N-(1-cyano-2,3-dihydro-1H-inden-5-yl)acetamide 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.