Technology Process of 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile
There total 16 articles about 3-((3R,9aS)-8-((R)-5-( 1H-tetrazol-1-yl)-2,3-dihydro-1H-indene-1-carbonyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bis(triphenylphosphine)palladium(II) chloride / 1,4-dioxane / 22 h / 20 - 100 °C
1.2: 0.75 h / 0 - 5 °C
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
3.1: triethylamine; trifluoroacetic acid / dichloromethane / 24 h / 20 °C
3.2: 2 h / 20 °C
4.1: 1 h / 20 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 3 h / 20 °C
6.1: Chiralcel OD / methanol; acetonitrile; carbon dioxide / 35 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
With
bis(triphenylphosphine)palladium(II) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; carbon dioxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide / trifluorormethanesulfonic acid / 1 h / 0 - 20 °C
2.1: bis(triphenylphosphine)palladium(II) chloride / 1,4-dioxane / 22 h / 20 - 100 °C
2.2: 0.75 h / 0 - 5 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C
4.1: triethylamine; trifluoroacetic acid / dichloromethane / 24 h / 20 °C
4.2: 2 h / 20 °C
5.1: 1 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 3 h / 20 °C
7.1: Chiralcel OD / methanol; acetonitrile; carbon dioxide / 35 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
With
N-Bromosuccinimide; bis(triphenylphosphine)palladium(II) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; trifluorormethanesulfonic acid; carbon dioxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl acetamide / 16 h / 80 °C / Inert atmosphere
2: N-Bromosuccinimide / trifluorormethanesulfonic acid / 1 h / 0 - 20 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine / ethanol / 4 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 0 - 20 °C
5: ethanol / 0.5 h / 150 °C / Microwave irradiation
6: cyanomethylenetributyl-phosphorane / benzene / 16 h / 100 °C
7: Chiralpak AD / n-heptane; isopropyl alcohol
8: 1 h / 20 °C
9: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 3 h / 20 °C
10: Chiralcel OD / methanol; acetonitrile; carbon dioxide / 35 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; cyanomethylenetributyl-phosphorane;
In
methanol; ethanol; n-heptane; dichloromethane; N,N-dimethyl acetamide; trifluorormethanesulfonic acid; carbon dioxide; isopropyl alcohol; acetonitrile; benzene;
