1616595-98-2

Upstream product

• 314741-40-7 (3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester 
• 1443739-27-2 (S)-tert-butyl 3-(hydroxymethyl)-4-(2-(3-nitrophenyl)-2-oxoethyl)piperazine-1-carboxylate 
• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 1616595-97-1 (9aS)-tert-butyl 3-(3-nitrophenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 

Downstream Products

• 1443737-33-4 tert-butyl (3R,9aS)-3-[3-(1H-tetrazol-1-yl)phenyl]hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate 

Relevant academic research and scientific papers

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.