314741-40-7

Basic information

• Product Name: (S)-4-N-Boc-2-(hydroxymethyl)piperazine
• Synonyms: (S)-1-Boc-3-hydroxymethyl-piperazine;(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;(S)-4-Boc-2-(Hydroxymethyl)piperazine;H57160;1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3S)-;(S)-4-N-Boc-2-hydroxyMeth...;(S)-1-Boc-3-(hyroxyMethyl)piperazine;tert-butyl (3S)-3-(hydroxyMethyl)piperazine-1-carboxylate
• CAS NO: 314741-40-7
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.2774
• Product Categories: Piperaizine
• Mol File: 314741-40-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 149.1 °C
• Appearance: /
• Density: 1.085 g/cm³
• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: (S)-4-N-Boc-2-(hydroxymethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-N-Boc-2-(hydroxymethyl)piperazine(314741-40-7)
• EPA Substance Registry System: (S)-4-N-Boc-2-(hydroxymethyl)piperazine(314741-40-7)

Safety Data

• Hazardous Substances Data: 314741-40-7(Hazardous Substances Data)

Usage

Uses

(S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 848482-93-9 (S)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 
• 958635-12-6 di-tert-butyl (2S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate 
• 958635-19-3 1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate 
• 788799-69-9 (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 958635-18-2 tert-butyl (8aS)-3-oxotetrahydro-1,3-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate 
• 126872-94-4 (S)-2-hydroxymethylpiperazine 
• 314741-39-4 O₁-tert-butyl O₃-methyl (3S)-piperazine-1,3-dicarboxylate 

Downstream Products

• 1070295-55-4 (S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide 
• 947276-26-8 (S)-tert-butyl 4-benzyl-3-(hydroxymethyl)piperazine-1-carboxylate 
• 155225-18-6 (S)-(4-methyl-piperazin-2-yl)-methanol 
• 317829-98-4 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde 

Relevant articles and documents

PIPERAZINES AS ANTI-OBESITY AGENTS

The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds, to processes for their preparation, and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

A practical synthesis of differentially protected 2-(Hydroxymethyl) piperazines

(Chemical Equation Presented) An efficient and scalable synthesis of three differentially protected 2-(hydroxymefhyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.

Compounds and methods for the treatment of neoplastic disease

A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.