314741-40-7

Usage

Uses

(S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m0/s1

Upstream product

• 958635-18-2 tert-butyl (8aS)-3-oxotetrahydro-1,3-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate 
• 314741-39-4 O₁-tert-butyl O₃-methyl (3S)-piperazine-1,3-dicarboxylate 
• 848482-93-9 (S)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 126872-94-4 (S)-2-hydroxymethylpiperazine 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 
• 958635-12-6 di-tert-butyl (2S)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate 
• 958635-19-3 1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate 
• 788799-69-9 (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 

Downstream Products

• 1070295-55-4 (S)-N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(hydroxymethyl)piperazin-1-yl)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-5-fluoro-4-methylbenzamide 
• 947276-26-8 (S)-tert-butyl 4-benzyl-3-(hydroxymethyl)piperazine-1-carboxylate 
• 155225-18-6 (S)-(4-methyl-piperazin-2-yl)-methanol 
• 317829-98-4 1-benzyloxycarbonyl-4-(tert-butyloxycarbonyl)piperazine-2-carboxaldehyde 

Relevant academic research and scientific papers

PIPERAZINES AS ANTI-OBESITY AGENTS

The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds, to processes for their preparation, and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

RENIN INHIBITORS

Compounds, pharmaceutical compositions, kits, article of manufacture, methods of using, and method of preparing of compounds having the formula of : wherein the variables are as defined herein.

A practical synthesis of differentially protected 2-(Hydroxymethyl) piperazines

(Chemical Equation Presented) An efficient and scalable synthesis of three differentially protected 2-(hydroxymefhyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries.

QUINOLINE DERIVATIVES AS ANTIBACTERIALS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or N-oxide thereof: corresponding novel medicaments, pharmaceutical compositions and/or methods of

Compounds and methods for the treatment of neoplastic disease

A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.