16166-53-3Relevant articles and documents
Regio- and stereoselective ring-opening of epoxides using organic dithiophosphorus acids as nucleophiles
Li, Zhaoming,Zhou, Zhenghong,Li, Kangying,Wang, Lixin,Zhou, Qilin,Tang, Chuchi
, p. 7609 - 7611 (2002)
A practical method for the synthesis of β-hydroxymercaptans has been successfully developed through the ring-opening of epoxides with organic dithiophosphorus acids 1. Highly regio- and stereoselective products, β-hydroxyalkyl dithiophosphates, which were transformed to the corresponding synthetically valuable β-hydroxymercaptans by further reduction, were obtained under mild reaction conditions without any catalyst or promoter. Highly enantioselective ring-opening reaction of cyclohexene epoxide with 1 was realized in the presence of a chiral (salen)Ti(IV) complex.
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Behringer,Kley
, p. 160,166 (1955)
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PEPTIDE CONJUGATES OF CYTOTOXINS AS THERAPEUTICS
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, (2021/01/25)
The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.
Regio- and enantioselective ring-opening of epoxides with HMDST: A straightforward access to 1,2-mercaptoalcohols
Degl'Innocenti, Alessandro,Capperucci, Antonella,Cerreti, Arianna,Pollicino, Salvatore,Scapecchi, Serena,Malesci, Irene,Castagnoli, Giulio
, p. 3063 - 3066 (2007/10/03)
TBAF-catalyzed reaction of a range of substituted epoxides with hexamethyldisilathiane smoothly affords a direct and simple access to β-mercaptoalcohols in a highly regio- and stereo-selective way. Georg Thieme Verlag Stuttgart.
