1616632-71-3 Usage
Description
[5-(2,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid is a complex organic compound characterized by a thiazolidine ring with a thioxo group and an acetic acid moiety. The benzylidene group within its structure features two methoxy substituents, which play a significant role in the compound's solubility and potential pharmacological activities. This molecule holds promise for applications in medicinal chemistry, particularly in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
[5-(2,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid is used as a key intermediate for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. Its potential in drug discovery and development makes it a valuable target for further research and exploration.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, [5-(2,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid serves as a promising candidate for the development of new drugs targeting a range of therapeutic areas. Its chemical properties and structural features allow for the possibility of creating innovative and effective treatments.
Used in Drug Design and Development:
[5-(2,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid is utilized in drug design and development processes to create novel therapeutic agents with improved efficacy and selectivity. Its unique structure and functional groups make it an attractive starting point for the design of new drugs with potential applications in various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1616632-71-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,6,6,3 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1616632-71:
(9*1)+(8*6)+(7*1)+(6*6)+(5*6)+(4*3)+(3*2)+(2*7)+(1*1)=163
163 % 10 = 3
So 1616632-71-3 is a valid CAS Registry Number.
1616632-71-3Relevant articles and documents
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR)
Zingle, Catherine,Tritsch, Denis,Grosdemange-Billiard, Catherine,Rohmer, Michel
, p. 3713 - 3719 (2014/07/07)
To develop more effective inhibitors than fosmidomycin, a natural compound which inhibits the deoxyxylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the MEP pathway, we designed molecules possessing on the one hand a catechol that is able to chelate the magnesium dication and on the other hand a group able to occupy the NADPH recognition site. Catechol-rhodanine derivatives (1-6) were synthesized and their potential inhibition was tested on the DXR of Escherichia coli. For the inhibitors 1 and 2, the presence of detergent in the enzymatic assays led to a dramatic decrease of the inhibition suggesting, that these compounds are rather promiscuous inhibitors. The compounds 4 and 5 kept their inhibition capacity in the presence of Triton X100 and could be considered as specific inhibitors of DXR. Compound 4 showed antimicrobial activity against Escherichia coli. The only partial protection of NADPH against the inhibition suggested that the catechol-rhodanine derivatives did not settle in the coenzyme binding site. This paper points out the necessity to include a detergent in the DXR enzymatic assays to avoid false positive when putative hydrophobic inhibitors are tested and especially when the IC50, are in the micromolar range.
