1616729-60-2Relevant academic research and scientific papers
Heteroaryldifluoromethylation of organoborons catalyzed by palladium: Facile access to aryl(heteroaryl)difluoromethanes
Xiao, Yu-Lan,Zhang, Bo,Feng, Zhang,Zhang, Xingang
, p. 4822 - 4825 (2014)
A first example of Pd-catalyzed heteroaryldifluoromethylation of organoborons with bromodifluoromethylated heteroarenes has been described. The use of phosphine ligand PAd2(n-Bu)·HI is critical for the reaction efficiency. With use of this ligand, a wide range of aryl(heteroaryl)-difluoromethanes were obtained with high efficiency. The notable features of this reaction are its broad substrate scope and excellent functional group compatibility, thus providing a facile protocol for application in drug discovery and development.
Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids
Ma, Guobin,Wan, Wen,Hu, Qingyang,Jiang, Haizhen,Wang, Jing,Zhu, Shizheng,Hao, Jian
supporting information, p. 7527 - 7530 (2014/07/07)
A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development. the Partner Organisations 2014.
