1616732-44-5

Upstream product

• 88192-19-2 3-azidopropylamine 
• 58-54-8 ethacrynic acid 
• 1616732-43-4 2,5-dioxopyrrolidin-1-yl 2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetate 

Downstream Products

• 1616732-45-6 3-(3-((((1-(3-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetamido)propyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)oxy)propyl)-2-((1-(3-((((1-(3-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetamido)propyl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)oxy)propyl)quinolin-4(1H)-ylidene)methyl)beiizothiazol-3-ium iodide 

Relevant academic research and scientific papers

Protein-protein communication and enzyme activation mediated by a synthetic chemical transducer

The design and function of a synthetic chemical transducer that can generate an unnatural communication channel between two proteins is described. Specifically, we show how this transducer enables platelet-derived growth factor to trigger (in vitro) the catalytic activity of glutathione-s-transferase (GST), which is not its natural enzyme partner. GST activity can be further controlled by adding specific oligonucleotides that switch the enzymatic reaction on and off. We also demonstrate that a molecular machine, which can regulate the function of an enzyme, could be used to change the way a prodrug is activated in a programmable manner.

MOLECULAR SENSOR AND METHODS OF USE THEREOF

The present invention is directed to fluorescent molecular sensor based on thiazole orange as represented below for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.