1616792-39-2Relevant academic research and scientific papers
Enantioselective Copper-Catalyzed Intermolecular Cyanobenzoyldifluoromethylation of Alkenes: Access to Chiral β-Difluoroacyl Nitriles
Fang, Mougui,Wu, Pingjie,Wang, Xia,Xie, Ziyue,Hou, Yali,Liu, Yao,Wu, Jingjing,Wu, Fanhong
, p. 4107 - 4111 (2022/03/14)
A novel asymmetric copper-catalyzed intermolecular cyanobenzoyldifluoromethylation of alkenes with iododifluoromethyl ketones and TMSCN has been reported, which provides a particularly valuable route to access chiral β-difluoroacyl nitriles with excellent enantioselectivities. The method permits the efficient cyanation of varied β-difluoroacyl-benzylic radicals in mild conditions with high functional group tolerance. The reaction proceeds through a radical pathway. In order to get insight into the stereochemical outcome, computational mechanistic studies were conducted.
