1616797-50-2Relevant academic research and scientific papers
Approaches for the introduction of fluorinated substituents into [1,2,3]Triazolo[1,5-a]pyridines
Chiassai, Leonardo,Adam, Rosa,Drechslerová, Marcela,Ballesteros, Rafael,Abarca, Belén
, p. 44 - 50 (2014/07/07)
[1,2,3]Triazolo[1,5-a]pyridines functionalization with a trifluoromethyl group has been achieved for the first time using different synthetic strategies. Furthermore, these scaffolds have been employed as starting material in the synthesis of new 2,6-disubstituted pyridines containing the trifluoromethyl group, compounds that are not available using other methodologies. A fluorine-mediated triazolopyridine dimerisation is described, improving the previously known synthetic method. Preliminary studies focused on exploring triazolopyridines reactivity with electrophilic fluorine have revealed a new approach for the obtainment of imidazopyridines.
