1616831-12-9

Basic information

• Product Name: N-(5-bromo-3-fluoro-2-methoxy-phenyl)-2-[(E)-hydroxyimino]-acetamide
• Synonyms: N-(5-bromo-3-fluoro-2-methoxy-phenyl)-2-[(E)-hydroxyimino]-acetamide
• CAS NO: 1616831-12-9
• Molecular Weight: 291.077
• Mol File: 1616831-12-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(5-bromo-3-fluoro-2-methoxy-phenyl)-2-[(E)-hydroxyimino]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromo-3-fluoro-2-methoxy-phenyl)-2-[(E)-hydroxyimino]-acetamide(1616831-12-9)
• EPA Substance Registry System: N-(5-bromo-3-fluoro-2-methoxy-phenyl)-2-[(E)-hydroxyimino]-acetamide(1616831-12-9)

Safety Data

• Hazardous Substances Data: 1616831-12-9(Hazardous Substances Data)

Upstream product

• 239122-51-1 5-bromo-3-fluoro-2-methoxyaniline 
• 302-17-0 chloral hydrate 

Downstream Products

• 1616831-14-1 6-fluoro-4-(4-fluorophenyl)-7-methoxyindoline-2,3-dione 
• 1616831-16-3 6-bromo-7-fluoro-5-(4-fluorophenyl)-8-methoxyquinazolin-4(3H)-one 
• 1616831-17-4 7-fluoro-5-(4-fluoro-phenyl)-8-methoxy-3H-quinazolin-4-one 
• 1616831-18-5 7-fluoro-5,6-bis(4-fluorophenyl)-8-methoxyquinazolin-4(3H)-one 
• 1616831-11-8 7-fluoro-5,6-bis(4-fluorophenyl)-8-hydroxyquinazolin-4(3H)-one 

Relevant articles and documents

COMT INHIBITORS

The present invention relates to compounds of formula (I), wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.