1616860-47-9Relevant academic research and scientific papers
Regioselective benzylation of 2-deoxy-2-aminosugars using crown ethers: Application to a shortened synthesis of hyaluronic acid oligomers
Mukherjee, Chinmoy,Liu, Lin,Pohl, Nicola L. B.
supporting information, p. 2247 - 2256 (2014/07/21)
The combination of benzyl bromide, sodium hydroxide and 15-crown-5 in tetrahydrofuran is shown to be an efficient method for installing benzyl groups at both the 4- and 6-positions regioselectively directly from peracetylated N-trichloroacetyl-protected glucosamine and galactosamine. Application of this benzylation strategy proved to significantly shorten the synthetic route to hyaluronic acid tetra- and hexamers.
