1616862-36-2Relevant academic research and scientific papers
Synthesis of 4-diarylamino-3-iodo-2(5 h)-furanones via the simultaneous α -iodination and N β-arylation by an efficient difunctionalizable transfer reagent PhI(OAc)2
Xue, Fuling,Peng, Pai,Shi, Jie,Zhong, Mingli,Wang, Zhaoyang
supporting information, p. 1944 - 1956 (2014/07/07)
During the studies on the intramolecular cyclization of 4-arylamino-2(5H)-furanones via the Pd-catalyzed C-H activation, a kind of difunctionalization reaction caused by the designed oxidant PhI(OAc)2 [(diacetoxyiodo)benzene, DIB] was accidentally discovered. When 1.5 eq. DIB is used as a difunctionalizable transfer reagent in the 40 h reaction at 60°C and CH3CN as solvent, 4-diarylamino-3-iodo-2(5H)-furanones can be obtained with the yields of 57-91% (usually more than 73%). The simultaneous α-iodination and N β-arylation reaction without metal catalyst is efficient and convenient. This novel utilization with a greater atom economy provides a simple and practical conversion route for the synthesis of the potential biological 2(5H)-furanone compounds containing multifunctional groups.
