1616890-22-2

Upstream product

• 123-54-6 acetylacetone 
• 98488-09-6 1-azido-4-ethoxybenzene 
• 1017471-10-1 1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]ethanone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1616890-31-3 2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile 
• 1616890-40-4 2-{1-(4-chlorophenyl)-3-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3-oxopropyl}malononitrile 

Relevant academic research and scientific papers

Synthesis of β-cyanopropan-1-one derivates by domino reaction

Domino nucleophilic addition was used for four-component Al 2O3-catalyzed environmentally friendly synthesis of polysubstituted β-cyanopropan-1-one. Domino nucleophilic addition involves removal of the cyano group linked to active methylene by the action of KF, and direct addition to enones. The reaction's capability for nucleophilic attack is F- > CN- in DMF. The use of low-toxicity reagents hints that the reaction is more environmentally friendly than traditional approaches. This journal is the Partner Organisations 2014.