(E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one

Base Information

• Chemical Name: (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one
• CAS No.: 1616890-22-2
• Molecular Formula: C₂₀H₁₈ClN₃O₂
• Molecular Weight: 367.835

Synonyms:(E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one

Chemical Property of (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one

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Technology Process of (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one

There total 3 articles about (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]ethanone (1017471-10-1) + 4-chlorobenzaldehyde (104-88-1) → (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one (1616890-22-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 - 25 ℃; for 6h;

DOI:10.1039/c4gc00386a

Reference yield:

acetylacetone (123-54-6,81235-32-7) → (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one (1616890-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 11 h / 0 - 5 °C / Reflux

2: potassium hydroxide / ethanol; water / 6 h / 0 - 25 °C

With sodium methylate; potassium hydroxide; In methanol; ethanol; water;

DOI:10.1039/c4gc00386a

Reference yield:

1-azido-4-ethoxybenzene (98488-09-6) → (E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one (1616890-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 11 h / 0 - 5 °C / Reflux

2: potassium hydroxide / ethanol; water / 6 h / 0 - 25 °C

With sodium methylate; potassium hydroxide; In methanol; ethanol; water;

DOI:10.1039/c4gc00386a

upstream raw materials:

acetylacetone

1-azido-4-ethoxybenzene

1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]ethanone

4-chlorobenzaldehyde

Downstream raw materials:

2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

2-{1-(4-chlorophenyl)-3-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3-oxopropyl}malononitrile

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