161692-17-7

Upstream product

• 917-61-3 sodium isocyanate 
• 161692-16-6 1-(1-amino-1-cyanomethyl)-1-ethoxycarbonyl cyclopropane 
• 161692-19-9 1-(4,4,6-trimethyl-[1,3]oxazinan-2-yl)-cyclopropanecarboxylic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 33329-69-0 1-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl)-cyclopropanecarboxylic acid ethyl ester 
• 33329-70-3 ethyl 1-formylcyclopropane-1-carboxylate 
• 1558-81-2 1-carbethoxy-1-cyanocyclopropane 

Relevant academic research and scientific papers

Latent inhibitors part 11. The synthesis of 5-spirocyclopropyl dihydroorotic acid

Approaches to the synthesis of 5-spirocyclopropyldihydroorotic acid are described. Difficulties were encountered in the lack of reactivity of diethyl 2-oxobutandicarboxylate and its derivatives towards cyclopropanation. Potential intermediates were prepar