1558-81-2

Basic information

• Product Name: ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE
• Synonyms: ETHYL 1-CYANO-1-CYCLOPROPANECARBOXYLATE;ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE;1-CYANO-CYCLOPROPANECARBOXYLIC ACIDETHYL ESTER;Cyclopropanecarboxylic acid, 1-cyano-, ethyl ester;Ethyl 1-cyano-1-cyclopropanecarboxylate 96%;ethyl 1-cyanocyclopropane-1-carboxylate;1-cyano-1-cyclopropanecarboxylic acid ethyl ester;1-cyanocyclopropane-1-carboxylic acid ethyl ester
• CAS NO: 1558-81-2
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• Product Categories: C6 to C7;Carbonyl Compounds;Esters;Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 1558-81-2.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 217 °C(lit.)
• Flash Point: 211 °F
• Appearance: /
• Density: 1.077 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0996mmHg at 25°C
• Refractive Index: n20/D 1.445(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE(1558-81-2)
• EPA Substance Registry System: ETHYL 1-CYANOCYCLOPROPANECARBOXYLATE(1558-81-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• WGK Germany: 3
• TSCA: No
• HazardClass: IRRITANT
• Hazardous Substances Data: 1558-81-2(Hazardous Substances Data)

Usage

Uses

Ethyl 1-cyano-1-cyclopropanecarboxylate may be used as a monomer in the preparation of poly(ethyl trimethylene-1-cyano-1-carboxylate)s.

General Description

Ethyl 1-cyano-1-cyclopropanecarboxylate (ethyl 1-cyanocyclopropanecarboxylate) is an alkyl 1-cyanocyclopanecarboxylate. It can be prepared by reacting ethyl cyanoacetate, 1,2-dibromoethane, potassium carbonate and DMSO.

InChI:InChI=1/C7H9NO2/c1-2-10-6(9)7(5-8)3-4-7/h2-4H2,1H3

Upstream product

• 106-93-4 ethylene dibromide 
• 105-56-6 ethyl 2-cyanoacetate 
• 107-04-0 1-Bromo-2-chloroethane 
• 20144-11-0 (2-Methylmercapto-ethyl)-malononitril 
• 64648-13-1 S-ethenyl-S-(4-methylphenyl)-N-tosylsulfilimine 
• 107-06-2 1,2-dichloro-ethane 
• 64-17-5 ethanol 
• 20144-19-8 (2-Dimethylsulfonio-ethyl)-malononitril-Kation 

Downstream Products

• 33329-69-0 1-(4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-yl)-cyclopropanecarboxylic acid ethyl ester 
• 45434-02-4 (1-(aminomethyl)cyclopropyl)methanol 
• 400840-94-0 1-aminomethylcyclopropanecarboxylic acid ethyl ether 
• 153248-46-5 1-hydroxymethyl-1-(tert-butoxycarbonylaminomethyl)cyclopropane 
• 18719-42-1 diethyl 2-chloroethylmalonate 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 119612-29-2 1-Cyano-cyclopropanecarboxylic acid isopropylamide 
• 119612-28-1 Ethyl 2-cyano-4-(isopropylamino)butanoate 
• 6914-74-5 1-aminocarbonylcyclopropanecarboxylic acid 
• 6914-79-0 1-cyano-cyclopropanecarboxylic acid 
• 1559-04-2 1-cyanocyclopropane-1-carboxamide 

Relevant articles and documents

Electrosynthesis of cyclopropane derivatives by a Perkin-type reaction

Electrolysis of active methylene compounds at a Pt cathode in MeCN in the presence of vicinal dihaloalkanes leads to cyclopropane derivatives in yields up to 90percent.In the cases of CH-acids with low pKa it is expedient to apply more active dihaloalkanes, while for CH-acids with higher pKa the desired product yields may be raised using electrogenerated bases. - Key words: CH-acids; 1,2-dihaloalkanes; cyclopropanes; electrosynthesis; electroreduction; electronegative bases; azobenzene.

Synthesis, bioactivity, theoretical and molecular docking study of 1-cyano-N-substituted-cyclopropanecarboxamide as ketol-acid reductoisomerase inhibitor

Ketol-acid reductoisomerase (KARI; EC 1.1.1.86) catalyzes the second common step in branched-chain amino acid biosynthesis. The catalyzed process consists of two stages, the first of which is an alkyl migration from one carbon atom to its neighbouring ato

A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols

A reaction of alk-4-ynals with aliphatic amino alcohols or 2-aminoethanethiol in the system DMSO - KOH gives bicyclic N,O- and N,S-enaminals: 6-methylidenehexahydro-2H-pyrrolo[2,1-b][1,3]oxazines, 5-methylidenehexahydropyrrolo[2,1-b]oxazoles, or 5-methyl-

A class of chiral beta-hydroxyamide compounds, preparation method and applications thereof,

The invention discloses a chiral beta-hydroxyamide compound and a preparation method thereof, wherein the compound is represented by a formula I. According to the invention, the raw material for preparing a non-natural chiral amino acid compound is obtained by carrying out catalytic hydrolysis on a prochiral diamide compound II with different substituents by using a Rhodococcus erythropolis AJ270microbial system, wherein the use amount of the Rhodococcus erythropolis can be adjusted according to the use amount of a substrate, the reaction solvent is a common buffer solution with the pH valueof 6.0-8.0, the temperature is 20-37 DEG C, the reaction time is 3-120 h, and the Rhodococcus erythropolis microbial catalytic system can be cultured through fermentation and conveniently stored; andwith the application of the biotransformation to prepare chiral monoamide carboxylic acid and dicarboxylic acid, the characteristics of simplicity and convenience in operation, high reaction efficiency, mild reaction conditions, high enantioselectivity, easiness in product separation and high product purity are achieved, and the application prospect is god.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.