161692-81-5

Basic information

• Product Name: 4-(2',4'-Difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid
• Synonyms: 4-(2',4'-Difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid
• CAS NO: 161692-81-5
• Molecular Formula: C₁₇H₁₂F₂O₃
• Molecular Weight: 302.27
• Mol File: 161692-81-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 490.4°Cat760mmHg
• Flash Point: 250.4°C
• Appearance: /
• Density: 1.293g/cm³
• PKA: 3.73±0.11(Predicted)
• CAS DataBase Reference: 4-(2',4'-Difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2',4'-Difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid(161692-81-5)
• EPA Substance Registry System: 4-(2',4'-Difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid(161692-81-5)

Safety Data

• Hazardous Substances Data: 161692-81-5(Hazardous Substances Data)

Upstream product

• 37847-52-2 2,4-difluorobiphenyl 
• 2170-03-8 itaconic acid anhydride 
• 97-65-4 2-methylenesuccinic acid 

Downstream Products

• 170950-57-9 5-(2',4'-Difluoro-biphenyl-4-yl)-5-hydroxy-3-methyl-5H-furan-2-one 
• 112344-52-2 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid 

Relevant articles and documents

4-(2',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID AND ITS DERIVATIVES

Friedel-Crafts reaction of itaconic anhydride (III) with 2,4-difluorobiphenyl (II) afforded unsaturated acid IV which was hydrogenated to give 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acod (I).A series of functional derivatives and salts of the acid I has been prepared.The antiinflammatory effect of these compounds was compared with that of acid I using selected experimental inflammation models.The analgesic activity in the intraperitoneal iritation test was also evaluated.In the case of (R)-(+)-1-phenylethylamide Vf the ratio of the diastereisomers was determined by HPLC.