37847-52-2Relevant articles and documents
Pd nanoparticles in silica hollow spheres with mesoporous walls: A nanoreactor with extremely high activity
Chen, Zhe,Cui, Zhi-Min,Niu, Fang,Jiang, Lei,Song, Wei-Guo
, p. 6524 - 6526 (2010)
A true nanoreactor composed of mesoporous silica hollow spheres and Pd nanoparticles residing inside the spheres shows superior activity in Suzuki coupling reactions with 99.5% yield in 3 min.
An efficient heterogeneous Pd catalyst for the Suzuki coupling: Pd/Al 2O3
Kudo, Daisuke,Masui, Yoichi,Onaka, Makoto
, p. 918 - 919 (2007)
PdII-loading alumina catalyst, which is simply prepared through impregnation of γ-alumina with Pd(OAc)2 followed by calcination in the air, shows a high catalytic activity for the Suzuki coupling of aryl bromides with arylboronic acids under phosphine ligand-free conditions. Only 0.25 mol% of palladium is sufficient for the promotion of the couplings in ethanol. Copyright
Method for synthesizing biphenyl compounds by adopting microchannel reactor
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Paragraph 0045-0050, (2021/11/10)
The invention relates to a method for synthesizing biphenyl compounds by adopting a microchannel reactor. The method comprises the following steps: mixing a compound shown in a formula (1), a compound shown in a formula (2), a compound shown in a formula (3) and a copper catalyst in the microchannel reactor, carrying out diazotization coupling reaction, and purifying the obtained reaction product to obtain a compound shown in a formula (4). Compared with the prior art, the micro-channel reactor is adopted, so that the diazotization coupling reaction time is effectively shortened, the reaction stability and efficiency are improved, the reaction yield and purity are improved, and the method has the advantages of environmental protection, safety, simple process, low cost, continuous industrial production and the like.
Recombinant Peptide Fusion Protein-Templated Palladium Nanoparticles for Suzuki-Miyaura and Stille Coupling Reactions
Mosleh, Imann,Shahsavari, Hamid R.,Beitle, Robert,Beyzavi, M. Hassan
, p. 2942 - 2946 (2020/03/26)
This study examined the use of nanoparticles created with recombinant 45-amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki-Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb) and could be recycled. This study establishes a potentially cost-effective approach to prepare heterogeneous catalysts containing well-defined nanoparticles enabling key C?C bond formation leading to synthetically and pharmaceutically interesting compounds.