1617-37-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
(Z)-2-methylpent-2-enoic acid is utilized as a key intermediate in the synthesis of a wide range of pharmaceuticals and agrochemicals. Its unique chemical structure allows for the creation of diverse and effective compounds for these industries.
Used in Flavoring Agents for the Food and Beverage Industry:
(Z)-2-methylpent-2-enoic acid is employed as a flavoring agent in the food and beverage industry, capitalizing on its natural fruity aroma. It is considered safe for consumption in small amounts, adding a pleasant taste to various products.

InChI:InChI=1/C6H10O2/c1-3-4-5(2)6(7)8/h4H,3H2,1-2H3,(H,7,8)/b5-4-

Upstream product

• 124-38-9 carbon dioxide 
• 54653-29-1 (Z)-2-bromo-2-pentene 
• 107-87-9 2-Pentanone 
• 16957-70-3 2-methylpent-2-enoic acid 
• 28892-68-4 2-hydroxy-2-methyl-pentanoic acid 
• 1567-14-2 methyl (2E)-2-methyl-2-pentenoate 
• 4111-09-5 2-Hydroxy-2-methyl-pentanenitrile 

Downstream Products

• 54653-30-4 (E)-2-bromo-2-pentene 

Relevant academic research and scientific papers

A practical, stereoselective synthesis of (E)- and (Z)-2-bromo-2- pentenes

A short, stereoselective preparation of (E)-2-bromo-2-pentene and (Z)- 2-bromo-2-pentene is described starting from trans-2-methyl-2-pentenoic acid.

Structure-activity relationships of unsaturated analogues of valproic acid

The principal metabolite of valproic acid (VPA), 2-ene VPA, appears to share most of VPA's pharmacological and therapeutic properties while lacking its hepatotoxicity and teratogenicity, thus making it a useful lead compound for the development of safer antiepileptic drugs. Analogues of 2-ene VPA were evaluated for anticonvulsant activity in mice using the subcutaneous pentylenetetrazole test. Cyclooctylideneacetic acid exhibited a potency markedly exceeding that of VPA itself with only modest levels of sedation. Potency, as either ED50 or brain concentration, was highly correlated (r > 0.85) with volume and lipophilicity rather than with one of the shape parameters calculated by molecular modeling techniques, arguing against the existence of a specific receptor site. Instead, a role for the plasma membrane in mediating the anticonvulsant effect is suggested.