1617-98-7

Usage

Explanation

The compound is composed of 11 carbon atoms, 11 hydrogen atoms, 3 nitrogen atoms, and 1 oxygen atom.

Explanation

It belongs to a class of organic compounds containing a five-membered heterocyclic ring with oxygen and nitrogen atoms.

Explanation

The specific compound has an ethyl group (-CH2CH3) and a phenyl group (C6H5) attached to the oxadiazole ring, which influences its chemical properties and reactivity.

Explanation

It is used as a building block for the synthesis of various biologically active molecules, which can be further developed into potential drugs or therapeutic agents.

Explanation

The compound's specific properties, such as solubility, stability, and reactivity, as well as its potential applications in medicine and industry, are still being researched and explored.

Explanation

Due to its unique structure and properties, the compound can be used to create new molecules with potential biological activities, which can be beneficial in the development of new drugs or therapies.

Explanation

The oxadiazole ring is a characteristic feature of 1,3,4-Oxadiazol-2-amine, N-ethyl-5-phenyl-, which contributes to its chemical properties and reactivity in various chemical reactions.

Explanation

The presence of the ethyl and phenyl groups on the oxadiazole ring affects the compound's reactivity, making it suitable for use in the synthesis of various biologically active molecules.

Explanation

The compound's potential use in the development of new drugs and therapies is a primary focus of research, as it may lead to the discovery of novel treatments for various diseases and conditions.

Class

Oxadiazole derivative

Structure

Ethyl and phenyl groups attached to the oxadiazole ring

Application

Pharmaceutical research and development

Exploration

Specific properties and potential applications

Biological Activity

Potential use in the synthesis of biologically active molecules

Heterocyclic Ring

Five-membered ring with oxygen and nitrogen atoms

Chemical Reactivity

Influenced by the ethyl and phenyl groups

Research Focus

Development of new drugs and therapies

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 129521-40-0 4-ethyl-1-benzoyl semicarbazide 
• 14632-22-5 N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide; sodium salt 
• 98-88-4 benzoyl chloride 
• 26257-93-2 2-benzoyl-N-ethylhydrazinecarbothioamide 
• 14632-24-7 N-ethyl-N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide 

Downstream Products

• 113966-44-2 N-Ethyl-N-(5-phenyl-1,3,4-oxadiazol-2-yl)malonamic acid 
• 113966-37-3 Anhydro 8-ethyl-5-hydroxy-2-phenyl-7-oxo-1,3,4-oxadiazolo<3,2-a>pyrimidinium hydroxide 
• 88-06-2 2,4,6-Trichlorophenol 

Relevant academic research and scientific papers

A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera

2-Amino-substituted oxadiazole derivatives and pharmaceutical composition comprising the same

The present invention provides: a novel 2-amino-substituted oxadiazole derivative represented by Chemical Formula 1 and having an excellent Wnt gene expression controlling activity; a pharmaceutically allowable salt of the same; a method for producing the

Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate

A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-

O -iodoxybenzoic acid mediated oxidative desulfurization initiated domino reactions for synthesis of azoles

A systematic exploration of thiophilic ability of o-iodoxybenzoic acid (IBX) for oxidative desulfurization to trigger domino reactions leading to new methodologies for synthesis of different azoles is described. A variety of highly substituted oxadiazoles, thiadiazoles, triazoles, and tetrazoles have been successfully synthesized in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthiourea, 1,3-disubtituted thiourea, and thioamides.

Oxadiazoles in medicinal chemistry

Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities. The current study presents a systematic comparison of 1,2,4- and 1,3,4-oxadiazole matched pairs in the AstraZeneca compound collection. In virtually all cases, the 1,3,4-oxadiazole isomer shows an order of magnitude lower lipophilicity (log D), as compared to its isomeric partner. Significant differences are also observed with respect to metabolic stability, hERG inhibition, and aqueous solubil ity, favoring the 1,3,4-oxadiazole isomers. The difference in profile between the 1,2,4 and 1,3,4 regioisomers can be rationalized by their intrinsically different charge distributions (e.g., dipole moments). To facilitate the use of these heteroaromatic rings, novel synthetic routes for ready access of a broad spectrum of 1,3,4-oxadiazoles, under mild conditions, are described.