16171-40-7Relevant academic research and scientific papers
Westphal Reaction in Solid-Phase
Delgado, Francisca,Linares, M. Lourdes,Alajarin, Ramon,Vaquero, Juan J.,Alvarez-Builla, Julio
, p. 4057 - 4060 (2003)
(Equation presented) A library of cycloimonium salts has been prepared through Westphal reaction in solid-phase. By reaction of solid-support-bound azolium or azinium acetates 2, 1,2-diketones 4, and base, cycloimonium salts 5 were synthesized in good to high yield and purities.
Microwave assisted Westphal condensation and its application to synthesis of sempervirine and related compounds
Chinta Rao,Saha, Sanjay,Raolji, Gajendra B.,Patro, Balaram,Risbood, Prabhaker,Difilippantonio, Michael J.,Tomaszewski, Joseph E.,Malhotra, Sanjay V.
, p. 487 - 490 (2013/02/25)
A concise synthesis of a potent lead in anticancer therapeutics, sempervirine, was achieved by one pot Westphal condensation, ester hydrolysis, and decarboxylation under microwave irradiation. The method was extended to the synthesis of several similar he
2-Methylpyridinium Salts as 1,4-Dinucleophiles. Quinolizinium Salts from the Westphal Condensation
Alvarez-Builla, J.,Trigo, G. Gonzales,Ezquerra, J.,Fombella, M.E.
, p. 681 - 685 (2007/10/02)
Condensation of 2-methylpyridinium salts with 1,2-dicarbonyls in the presence of base, yielded 2,3-disubstituted quinolizinium compounds.Results obtained with different pyridinium substrates are discussed.
