161715-28-2

Upstream product

• 13578-58-0 2-ethylamino-2-thiazoline 
• 886615-18-5 S-(azetidin-3-yl) ethanethioate 
• 23994-89-0 2-(ethylthio)-2-thiazoline 
• 161715-27-1 1-(1,3-thiazolin-2-yl-)azetidin-3-ol 
• 179337-62-3 3-methanesulfonyloxy-1-(1,3-thiazolin-2-yl)azetidine 

Downstream Products

• 161715-24-8 tebipenem 
• 161715-20-4 (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-{[1-(2-thiazolin-2-yl)-3-azetidinyl]sulfanyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid-p-nitrobenzyl ester 
• 161715-21-5 Tebipenem 

Relevant academic research and scientific papers

Tebipenem pivoxil intermediate and synthesis method and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a tebipenem pivoxil intermediate and a synthesis method and application thereof. The synthesis method comprises the following steps: with ethylamine and chloroacetamide

A more than the penem matching bends down the ester side chain new synthetic method

The invention discloses a novel synthetic method of a tebipenem pivoxil side chain. The method employs cheap and easily available raw material, has simple experimental operations, high overall yield and is applicable to industrialized production.

Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084

We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl- 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. Japan Antibiotics Research Association.

Carbapenem-3-carboxylic acid ester derivatives

Disclosed are carbapenem-3-carboxylic acid ester derivatives of formula (I), wherein R1 is a hydrogen atom or a lower alkyl group, R2 is an alkyl group which may be substituted by a cycloalkyl group having about 4 to 7 carbon atoms and which may be substituted by a lower alkyl group, or is a cycloalkyl group having 4 to 7 carbon atoms which may be substituted by a lower alkyl group and n is 0 or 1. The compounds are highly absorbable through the digestive tract and are rapidly converted in the body to the active compound, which shows strong antibacterial activity. STR1