161715-28-2

Basic information

• Product Name: 3-Acetylthio-1-(1,3-thiazolin-2-yl)azetidine
• Synonyms: 3-Acetylthio-1-(1,3-thiazolin-2-yl)azetidine;Ethanethioic acid,S-[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl] ester
• CAS NO: 161715-28-2
• Molecular Formula: C₈H₁₂N₂OS₂
• Molecular Weight: 216.32368
• EINECS: -0
• Product Categories: API
• Mol File: 161715-28-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 349.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: 3-Acetylthio-1-(1,3-thiazolin-2-yl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetylthio-1-(1,3-thiazolin-2-yl)azetidine(161715-28-2)
• EPA Substance Registry System: 3-Acetylthio-1-(1,3-thiazolin-2-yl)azetidine(161715-28-2)

Safety Data

• Hazardous Substances Data: 161715-28-2(Hazardous Substances Data)

Upstream product

• 13578-58-0 2-ethylamino-2-thiazoline 
• 886615-18-5 S-(azetidin-3-yl) ethanethioate 
• 23994-89-0 2-(ethylthio)-2-thiazoline 
• 161715-27-1 1-(1,3-thiazolin-2-yl-)azetidin-3-ol 
• 179337-62-3 3-methanesulfonyloxy-1-(1,3-thiazolin-2-yl)azetidine 

Downstream Products

• 161715-21-5 Tebipenem 
• 161715-20-4 (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-{[1-(2-thiazolin-2-yl)-3-azetidinyl]sulfanyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid-p-nitrobenzyl ester 
• 161715-24-8 tebipenem 

Relevant articles and documents

Tebipenem pivoxil intermediate and synthesis method and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a tebipenem pivoxil intermediate and a synthesis method and application thereof. The synthesis method comprises the following steps: with ethylamine and chloroacetamide

Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084

We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl- 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. Japan Antibiotics Research Association.