161723-00-8

Basic information

• Product Name: (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE
• Synonyms: (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE;(3R,4R)-3,4-Pyrrolidinediylbis-Carbamic Acid Bis(1,1-Dimethylethyl) Ester;trans tert-Butyl 3,4-diaminopyrrolidine-1-carboxylate
• CAS NO: 161723-00-8
• Molecular Formula: C₁₄H₂₇N₃O₄
• Molecular Weight: 301.38
• Mol File: 161723-00-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 433.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• PKA: 11.63±0.40(Predicted)
• CAS DataBase Reference: (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE(161723-00-8)
• EPA Substance Registry System: (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE(161723-00-8)

Safety Data

• Hazardous Substances Data: 161723-00-8(Hazardous Substances Data)

Usage

General Description

(R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE is a chemical compound that is a diamine derivative of pyrrolidine. It is a white to off-white solid that is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. The "R,R" in its name indicates that the molecule has two stereocenters, and they both have an "R" configuration. The N-BOC group is a protective group for the amine functional group, which allows for selective reactions to be carried out without affecting the amine. Overall, (R,R)-3,4-TRANS-(N-BOC)-DIAMINOPYRROLIDINE is a key building block in organic synthesis that is commonly used in the pharmaceutical and chemical industries.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 205251-35-0 N-benzyl-3,4-di(Boc-amino)pyrrolidine 

Downstream Products

• 161723-01-9 4-((3R,4R)-3,4-Bis-tert-butoxycarbonylamino-pyrrolidin-1-yl)-4-oxo-butyric acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester 
• 205251-42-9 7-((3R,4R)-3,4-Bis-tert-butoxycarbonylamino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 247048-25-5 4-((3R,4R)-3,4-Bis-tert-butoxycarbonylamino-pyrrolidin-1-yl)-4-oxo-butyric acid 2-{ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethyl ester 

Relevant articles and documents

Synthesis of an ovoid chiral cage

Evidence for the formation of an ovoid chiral cage, resulting from the auto-assembly of two hexafunctional and three tetrafunctional modules reacting through dynamic covalent bond formation, is provided. Georg Thieme Verlag Stuttgart.

Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part

With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R = Disperse Red 1) with the bis(aminomethyl)benzoic acid hinge selectively bound the tripeptide shown below on the right (K(a) = 4100 M-1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to large and diverse synthetic receptor libraries.

Sequence-Selective Peptide Binding with a Synthetic Receptor

A dye-labeled variant of a highly substrate-selective synthetic receptor for peptides is described and its binding selectivity for certain di- and tripeptide sequences is elucidated using an encoded combinatorial library.