161727-77-1

Basic information

• Product Name: 4-Chloro-2,2'-bipyridine
• Synonyms: 4-Chloro-2,2'-bipyridine
• CAS NO: 161727-77-1
• Molecular Formula: C10H7ClN2
• Molecular Weight: 0
• Product Categories: API intermediates
• Mol File: 161727-77-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-2,2'-bipyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2,2'-bipyridine(161727-77-1)
• EPA Substance Registry System: 4-Chloro-2,2'-bipyridine(161727-77-1)

Safety Data

• Hazardous Substances Data: 161727-77-1(Hazardous Substances Data)

Upstream product

• 366-18-7 [2,2]bipyridinyl 
• 14163-02-1 4-chloro-2-(pyridin-2-yl)pyridine N-oxide 
• 109-04-6 2-bromo-pyridine 
• 1121-76-2 4-chloropyridine N-oxide 
• 139585-50-5 4-chloro-2-trimethylsilylpyridine 
• 14163-00-9 4-nitro-2,2'-bipyridine N-oxide 
• 33421-43-1 2,2'-bipyridyl N-oxide 

Relevant articles and documents

Synthesis of unsymmetrically substituted bipyridines by palladium-catalyzed direct C-H arylation of pyridine N -oxides

Chemical equations presented. Substituted bipyridines were efficiently prepared by direct coupling between pyridine N-oxides and halopyridines using a palladium catalyst. Pyridine N-oxides with electron-withdrawing substitutents gave the best yields. This method allows the convenient preparation of 2,2′-, 2,3′-, and 2,4′-bipyridines which are useful as functionalized ligands for metal complexes or as building blocks for supramolecular architectures.

Hiyama cross-coupling of chloro-, fluoro-, and methoxypyridyltrimethylsilanes: Room-temperature novel access to functional bi(het)aryl

(Chemical Equation Presented) The incorporation of chloro, fluoro, or methoxy substituents on the pyridine ring of pyridyltrimethylsilanes allowed us to perform efficient Hiyama cross-coupling with various (het)aryl halides. The reactions proceeded smoothly at room temperature leading to the corresponding functional bis(het)aryl in fair to excellent yields. The presence of pyridine nitrogen α to the trimethylsilyl group was requisite to achieve the cross-coupling.

6-Amino-2,2'-bipyridine as a new fluorescent organic compound

6,6'-Diamino-2,2'-bipyridine (1a) has been found to exhibit a strong fluorescence in the near-UV region.Some amino and/or chloro substituted bipyridines (bpys) have been synthesized an studied to show that only 6-amino-substtuted derivatives exhibited a strong emission.The emission of 6-amino-6'-chloro-bpy (3a) was the strongest (λmax = 429.0 nm; Φ = 0.78 in ethanol) among them.On the other hand, little or no emission was observed for monochloro-, dichloro- and 4-amino- derivatives.