139585-50-5 Usage
General Description
4-Chloro-2-trimethylsilylpyridine is a chemical compound that is commonly used as a reagent in organic synthesis. It is known for its ability to activate and functionalize various aromatic and heteroaromatic compounds. The trimethylsilyl group in its structure makes it a valuable reagent for the protection of alcohols and phenols in organic chemistry. Additionally, its pyridine ring provides it with nucleophilic and basic properties, making it useful in a wide range of synthetic transformations. It is also used as a building block for the synthesis of pharmaceuticals and agrochemicals. However, it is important to handle 4-chloro-2-trimethylsilylpyridine with caution as it is a toxic and potentially hazardous substance.
Check Digit Verification of cas no
The CAS Registry Mumber 139585-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,5,8 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 139585-50:
(8*1)+(7*3)+(6*9)+(5*5)+(4*8)+(3*5)+(2*5)+(1*0)=165
165 % 10 = 5
So 139585-50-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H12ClNSi/c1-11(2,3)8-6-7(9)4-5-10-8/h4-6H,1-3H3
139585-50-5Relevant articles and documents
First regioselective c-2 lithiation of 3- and 4-chloropyridines
Choppin, Sabine,Gros, Philippe,Fort, Yves
, p. 603 - 606 (2007/10/03)
We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.
