16175-04-5Relevant academic research and scientific papers
DIHYDROBENZO[B][1]BENZOTHIEPIN COMPOUNDS USEFUL IN THERAPY
-
Page/Page column 29; 30; 31; 32; 38, (2019/05/30)
The present invention relates to the use of a compound of formula (I), to decrease or inhibit, in vitro or ex vivo, the Patched receptor drug efflux activity, in particular the chemotherapeutic drug efflux activity and chemotherapy resistance. The present disclosure further relates to uses of such compounds, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof. The compound of the invention can indeed be advantageously used, in combination with at least one chemotherapeutic drug, for treating cancer, for preventing cancer metastasis and/or for preventing cancer recurrence in a subject.
THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE
-
Page/Page column 26, (2009/10/01)
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibi
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors
Nuti, Elisa,Panelli, Laura,Casalini, Francesca,Avramova, Stanislava I.,Orlandini, Elisabetta,Santamaria, Salvatore,Nencetti, Susanna,Tuccinardi, Tiziano,Martinelli, Adriano,Cercignani, Giovanni,D'Amelio, Nicola,Maiocchi, Alessandro,Uggeri, Fulvio,Rossello, Armando
experimental part, p. 6347 - 6361 (2010/03/24)
Overexpression of macrophage elastase (MMP-12), a member of the matrix metalloproteinases family, can be linked to tissue remodeling and degradation in some inflammatory processes, such as chronic obstructive pulmonary disease (COPD), emphysema, rheumatoi
INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE
-
Page/Page column 61, (2008/06/13)
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibi
Derivatives of hydroxyphenylsulfanylbenzoic and hydroxphenylsulfanylarylacetic acids
-
, (2008/06/13)
Processes for the preparation of derivatives of hydroxyphenylsulfanylbenzoic and hydroxyphenylsulfanylarylacetic acids of Formula (I) and pharmaceutical compositions including these compounds are provided: wherein X is H, halogen or NO2group, n is 0 or 1, and m is 2 to 4 if Z is either 4-acetyl-3 -hydroxy-2-propylphenoxy of Formula (II): or a piperazinyl residue, or m is 1 if Z is quinolin-2-yl or 6-chloroquinoli-2-yl.
