1617526-97-2Relevant academic research and scientific papers
Enantioselective intramolecular propargylic amination using chiral copper-pybox complexes as catalysts
Shibata, Masashi,Nakajima, Kazunari,Nishibayashi, Yoshiaki
supporting information, p. 7874 - 7877 (2014/07/08)
Intramolecular propargylic amination of propargylic acetates bearing an amino group at the suitable position in the presence of chiral copper-pybox complexes proceeds enantioselectively to give optically active 1-ethynyl-isoindolines (up to 98% ee). The method described in this communication provides a useful synthetic approach to the enantioselective preparation of nitrogen containing heterocyclic compounds with an ethynyl group at the α-position. This journal is the Partner Organisations 2014.
