1617538-52-9Relevant academic research and scientific papers
Design of α7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [18F] quinuclidine derivative
Pin, Frédéric,Vercouillie, Johnny,Ouach, Aziz,Mavel, Sylvie,Gulhan, Zuhal,Chicheri, Gabrielle,Jarry, Christian,Massip, Stephane,Deloye, Jean-Bernard,Guilloteau, Denis,Suzenet, Franck,Chalon, Sylvie,Routier, Sylvain
, p. 214 - 224 (2014)
In this report, we describe the synthesis of a novel library of α7 nAChR ligands based on the modulation of the quinuclidine, quinazoline and tropane moieties. Spirane derivatives were newly synthesized under stereo specific 1,3 dipolar cylcoadditions. On
