1617540-47-2

Basic information

• Product Name: C₃₁H₃₇NO₄S₂Si
• Synonyms: C₃₁H₃₇NO₄S₂Si
• CAS NO: 1617540-47-2
• Molecular Weight: 579.857
• Mol File: 1617540-47-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₇NO₄S₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₇NO₄S₂Si(1617540-47-2)
• EPA Substance Registry System: C₃₁H₃₇NO₄S₂Si(1617540-47-2)

Safety Data

• Hazardous Substances Data: 1617540-47-2(Hazardous Substances Data)

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 1333480-90-2 3-(2-tert-butoxy-2-oxoethyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium bromide 
• 1333480-93-5 tert-butyl 2-(N-(3-(benzyldisulfanyl)-5-hydroxypent-2-en-2-yl)formamido)acetate 
• 1617540-46-1 C₃₅H₄₅NO₄S₂Si 

Relevant articles and documents

Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with "lock-in" function

A novel brain targeting l-ascorbic acid derivatives with "lock-in" function were designed and synthesized as prodrugs to achieve the effective delivery of ibuprofen to brain by glucose transporter 1 (GLUT1) and the Na+-dependent vitamin C transporter SVCT2. Ibuprofen-loaded four prodrugs were tested in the animals. Results from the in vivo distribution study after i.v. administration of these four prodrugs and naked ibuprofen indicated that four prodrugs exhibited excellent transport ability across the BBB and significantly increased the level of ibuprofen in brain. Among them, prodrugs 4 showed higher brain concentration. Both biodistribution data and pharmacokinetic parameters suggested that l-ascorbic acid thiamine disulfide delivery system was a promising carrier to enhance CNS drug's delivery ability into brain.