161768-95-2Relevant academic research and scientific papers
Synthesis and antimicrobial activity of benzimidazolyl/coumarinylmethoxyindoles
Gadaginamath, Guru S.,Joshi, Raghavendra G.
, p. 120 - 124 (2007/10/02)
Hydrolysis of substituted 5-ethoxycarbonylmethoxyindoles (2a-h), prepared by reacting 5-hydroxyindoles (1a-h) with ethyl chloroacetate, by ethanolic sodium hydroxide gives the corresponding diacids (3a-h) which on heating with o-phenylenediamine in 6N HCl undergo condensation and decarboxylation to give the substituted 5-(benzimidazol-2'-yl)methoxyindoles (4a-h).The diacid (3c) also undergoes decarboxylation on heating with 6N HCl producing indol-5-yloxyacetic acid (5c).Condensation of 5-hydroxyindoles (1a-h) with 4-bromomethyl-6-methyl coumarin (6) yield the expected coumarinylmethoxyindoles (7a-h).The newly synthesised biheterocycles have been screened for their antibacterial and antifungal activities.
