16179-66-1

Basic information

• Product Name: 2-Cyclohexen-1-one, 3-[(2-hydroxyethyl)amino]-
• CAS NO: 16179-66-1
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.197
• Mol File: 16179-66-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Cyclohexen-1-one, 3-[(2-hydroxyethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexen-1-one, 3-[(2-hydroxyethyl)amino]-(16179-66-1)
• EPA Substance Registry System: 2-Cyclohexen-1-one, 3-[(2-hydroxyethyl)amino]-(16179-66-1)

Safety Data

• Hazardous Substances Data: 16179-66-1(Hazardous Substances Data)

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 141-43-5 ethanolamine 

Downstream Products

• 2380-94-1 1H-indol-4-ol 
• 1932405-48-5 octahydropyrrolo[3,2-b]azepin-5(1H)one 
• 1332584-12-9 tert-butyl 4-oxooctahydro-1H-indole-1-carboxylate 
• 1821237-04-0 tert-butyl 4-hydroxyoctahydro-1H-indole-1-carboxylate 
• 877170-76-8 4-oxo-4,5,6,7-tetrahydro-indole-1-carboxylic acid tert-butyl ester 
• 13754-86-4 1,5,6,7-tetrahydro-indol-4-one 

Relevant articles and documents

Facile and efficient synthesis of pyrroles and indoles via palladium-catalyzed oxidation of hydroxy-enamines and -amines

The palladium-catalyzed oxidation of hydroxy-enamines, which were obtained by the condensation of β-aminoalcohols and carbonyl compounds, proceeded to give the corresponding polysubstituted pyrroles and 4,5,6,7-tetrahydroindoles in good yields. The treatment of o-(2-hydroxyethyl)aniline with the palladium catalyst also gave indole in 78% yield.

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

Efficient synthesis of pyrroles and 4,5,6,7-tetrahydroindoles via palladium-catalyzed oxidation of hydroxy-enamines

Facile and one-pot synthetic route of poly-substituted pyrroles and 4-oxo-4,5,6,7-tetrahydroindoles is established, which consists of three steps: (1) palladium-catalyzed oxidation of hydroxy-enamines by using tetrakis(triphenylphosphine)palladium and mesityl bromide oxidation system, (2) intramolecular cyclization, and (3) dehydration.