877170-76-8

Usage

Uses

Used in Transplant Medicine:
Tacrolimus is utilized as an immunosuppressive agent in the field of transplant medicine to prevent organ rejection. It is particularly effective in reducing the immune response against transplanted organs, such as kidneys, hearts, livers, and lungs, by inhibiting the activation of T-lymphocytes.
Used in Autoimmune Diseases:
In addition to its application in transplant medicine, Tacrolimus is also used in the treatment of various autoimmune diseases. It helps to suppress the overactive immune response that contributes to the progression of these conditions, such as atopic dermatitis, rheumatoid arthritis, and inflammatory bowel disease.
Used in Topical Treatments:
Tacrolimus is available in topical formulations, making it suitable for the treatment of skin conditions characterized by inflammation and immune dysregulation. Its application as a topical agent allows for targeted delivery to the affected area, minimizing systemic side effects.
Used in Ophthalmology:
In the field of ophthalmology, Tacrolimus is employed in the treatment of certain eye conditions, such as uveitis, where it helps to suppress the immune response and reduce inflammation within the eye.
Overall, 4,5,6,7-Tetrahydro-4-oxo-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester, or Tacrolimus, is a versatile and potent immunosuppressive agent with a wide range of applications in various medical fields, primarily focusing on transplant medicine, autoimmune diseases, topical treatments, and ophthalmology. Its ability to modulate the immune response makes it a valuable asset in the management of conditions where immune suppression is required for therapeutic success.

Upstream product

• 13754-86-4 1,5,6,7-tetrahydro-indol-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 504-02-9 1,3-cylohexanedione 
• 16179-66-1 3-((2-hydroxyethyl)amino)cyclohex-2-enone 
• 877170-89-3 Tert-butyl 4-((R,E)-4-(methoxycarbonyl)but-3-en-2-yl)-1H-indole-1-carboxylate 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 1821237-04-0 tert-butyl 4-hydroxyoctahydro-1H-indole-1-carboxylate 
• 1332584-12-9 tert-butyl 4-oxooctahydro-1H-indole-1-carboxylate 
• 1932405-48-5 octahydropyrrolo[3,2-b]azepin-5(1H)one 
• 543910-55-0 (-)-(3aR,4S,7aR)-4-hydroxy-4-(m-tolylethynyl)-octahydro-indole-1-carboxylic acid tert-butyl ester 
• 1821237-04-0 (3aRS,4SR,7aRS)-4-hydroxy-octahydro-indole-1-carboxylic acid tert-butyl ester 
• 1636881-61-2 methyl (3aR,4S,7aR)-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-3,3a,5,6,7,7a-hexahydro-2H-indole-1-carboxylate 
• 1332584-12-9 (-)-(3aR,7aR)-4-oxo-octahydro-indole-1-carboxylic acid tert-butyl ester 
• 1332584-12-9 (-)-(3aS,7aS)-4-oxo-octahydro-indole-1-carboxylic acid tert-butyl ester 
• 543906-20-3 (-)-furan-2-yl-((3aR,4S,7aR)-4-hydroxy-4-(m-tolylethynyl)-octahydro-indol-1-yl)-methanone 
• 877170-84-8 tert-butyl 4-((S,E)-3-(methoxycarbonyl)-1-(4-bromophenyl)allyl)-1H-indole-1-carboxylate 
• 877171-02-3 tert-butyl (S)-4-(1-(4-bromophenyl)-4-methoxy-4-oxobutyl)-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

Here we describe the identification, structure-activity relationship and the initial pharmacological characterization of AFQ056/mavoglurant, a structurally novel, non-competitive mGlu5 receptor antagonist. AFQ056/mavoglurant was identified by chemical der

4-Substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles and methods for making same

Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazo

C-H activation as a strategic reaction: Enantioselective synthesis of 4-substituted indoles

A method is described for the asymmetric synthesis of 4-substituted indoles from the Rh2(S-DOSP)4-catalyzed decomposition of vinyldiazoacetates in the presence of N-Boc-4-acetoxy-6,7-dihydroindole. The reaction proceeds via a combine