27292-49-5

Usage

Uses

Used in Pharmaceutical Industry:
3-MORPHOLINOPHENOL is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Dye Industry:
3-MORPHOLINOPHENOL is used as a chemical intermediate in the production of dyes, playing a role in the creation of colorants for various applications.
Used in Rubber Industry:
3-MORPHOLINOPHENOL is used as a chemical intermediate for the synthesis of rubber accelerators, which are essential in the manufacturing process of rubber products to enhance their properties.
Used in Polyester Resin Production:
3-MORPHOLINOPHENOL is used as an inhibitor in the production of polyester resins, helping to control the polymerization process and improve the quality of the final product.
Used in Corrosion Inhibition for Metals:
3-MORPHOLINOPHENOL is used as a corrosion inhibitor for metals, providing protection against oxidation and corrosion, thereby extending the lifespan of metal components and structures.

InChI:InChI=1/C10H13NO2/c12-10-3-1-2-9(8-10)11-4-6-13-7-5-11/h1-3,8,12H,4-7H2

Upstream product

• 110-91-8 morpholine 
• 108-46-3 recorcinol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 591-27-5 m-Hydroxyaniline 
• 106-41-2 4-bromo-phenol 
• 108-43-0 3-monochlorophenol 
• 26926-56-7 4-(3-benzyloxy-phenyl)-morpholine 
• 16179-67-2 3-morpholin-4-yl-cyclohex-2-enone 
• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 159724-40-0 3-morpholine-4-ylaniline 
• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 108-94-1 cyclohexanone 

Downstream Products

• 37895-11-7 μ-imido-dicarbonic acid ethyl ester 3-morpholin-4-yl-phenyl ester 
• 37895-05-9 1-morpholin-4-yl-3-phenylcarbamoyloxy-benzene 
• 27292-55-3 5-morpholin-4-yl-2-nitroso-phenol 
• 404009-40-1 IC₈₆₆₂₁ 
• 404009-46-7 AMA₃₇ 
• 25912-15-6 2-amino-5-morpholinophenol 
• 597584-59-3 3-morpholin-4-ylphenyl trifluoromethanesulfonate 
• 183307-22-4 3-[(3,5-difluoro-4-methyl-6-(3-(morpholin-4-yl)phenoxy)pyridin-2-yl)oxy]benzonitrile 
• 70362-07-1 2-hydroxy-4-morpholin-4-yl-benzaldehyde 
• 223133-36-6 t-butyl N-{5-[3-(morpholin-4-yl)phenoxy]-2-nitrophenyl}-N-methylcarbamate 
• 313655-18-4 2-[3-(4-Morpholinyl)phenoxy]ethyl 3-(1-piperazinyl)-2-pyrazinyl Ether 
• 205494-27-5 (3S,4R)-3-{N-benzyloxycarbonyl-β-(2-naphthyl)-L-alanyl}-amino-4-{3-(morpholin-4-yl)-phenoxy}-azetidin-2-one 
• 32040-09-8 4-(3-methoxyphenyl)morpholine 
• 1152500-29-2 C₁₄H₁₉NO₂ 

Relevant academic research and scientific papers

A novel morpholine-based rhodamine fluorescent chemosensor for the rapid detection of Hg2+ ions

A novel rhodamine-based receptor bearing a morpholine (RDM) was developed as a fluorescent chemosensor with high selectivity toward Hg2+. After the addition of Hg2+ to RDM, the color of the solution changed from colorless to pink, and the new absorption band appears at 580 nm. The fluorescent of RDM appears to orange color in the presence of Hg2+. Upon the addition of Hg2+, ring-opening of the corresponding spirolactam gives rise to fluorescence, and a 1:1 metal-ligand complex formed.

A long-wavelength fluorescent probe with a large Stokes shift for lysosome-targeted imaging of Cys and GSH

Biothiols including cysteine (Cys) and glutathione (GSH) are biological signaling molecules responsible for cell detoxification, cell metabolism and neutralization of reactive oxygen species. Here, we synthesized a long-wavelength fluorescent probe, DCIMA

Inter-alkane amidogen phenolic synthetic method (by machine translation)

Inter-alkane amidogen phenolic synthetic method, its characteristic is: 1st step, between the two alkane amidogen acyl aniline and sulfuric acid aqueous solution mixing and heating to 50 - 110 °C, thermal insulation reaction of aniline [...] sulfuric acid aqueous solution; 2nd step, continue to drip the sodium nitrite aqueous solution, sodium nitrite aqueous solution for dropping temperature of - 10 - 20 °C, drop bi yu 5 - 30 °C insulation, [...] aniline obtained diazonium salt of the sulfuric acid aqueous solution; 3rd step, [...] aniline diazonium salt of the sulfuric acid aqueous solution is directly heated to 45 - 110 °C, thermal insulation, in the hydrolysis reaction of the diazonium salt, cooling after treatment, to obtain the product between two alkane amidogen phenol; three-step required by the reaction of sulfuric acid in the 1st step reaction in the finished disposable adding; a three-step reaction in a finish step by step in the pot. The method of the invention with raw materials are cheap, abundant, synthetic high security of the process, the product yield is high, the three waste less pollution and the like, has high industrial value. (by machine translation)

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Method for continuously synthesizing meta-di-alkane aminophenol

The invention discloses a method for continuously synthesizing meta-di-alkane aminophenol. The technical scheme includes that continuous diazotization or continuous diazonium salt hydrolysis or continuous diazotization and diazonium salt hydrolysis is carried on raw materials such as di-alkane aminophenol, sodium nitrite and sulfuric acid, and after-treatment such as extraction is carried out to obtain the meta-di-alkane aminophenol which is a product. The method has the advantages that the raw materials can come from sufficient sources and are low in cost, processes for synthesizing the meta-di-alkane aminophenol are high in safety, products are high in yield, the method is little in waste gas, wastewater and industrial residue pollution, is green and environmental friendly and has a highindustrialization value, and the like.

Synthetic method for m-dialkylaminophenol

The invention provides a synthetic method for m-dialkylaminophenol. The synthetic method is characterized by comprising the following steps: step 1, adding an aqueous solution of sodium nitrite into an aqueous solution of sulfuric acid containing m-dialkylaminoaniline drop by drop at a temperature of -10 to 20 DEG C, and maintaining the obtained solution at a temperature of 5 to 30 DEG C for 1 to10 h after completion of the addition so as to obtain an aqueous solution of sulfuric acid containing m-dialkylaminoaniline diazohydrosulfate; and step 2, directly heating aqueous solution of sulfuricacid containing m-dialkylaminoaniline diazohydrosulfate to 45-110 DEG C, maintaining the solution at the temperature for 1-18 h, allowing m-dialkylaminoaniline diazohydrosulfate to undergo the hydrolysis reaction of a diazonium salt, and successively carrying out cooling and post-treatment so as to obtain the product dialkylaminophenol, wherein sulfuric acid needed in the first step and the second step is totally added in one shot in a first-step reaction, and the first-step diazotization reaction and the second-step hydrolysis reaction of the diazonium salt are carried out step by step in one pot. The method of the invention has the characteristics of low raw material price, sufficient raw material sources, high safety, high product yield, less three-wastes pollution and the like, and has high industrialization value.

N-(2-acetyl-4-morpholinophenyl amide derivatives for inducing differentiation of mesenchymal stem cells to endothelial cells

The present invention refers to mesenchymal stem cells the vascular endothelial cells inducing their differentiation to the rarity piperidinyl/molpholine for containing amide derivatives and provides use thereof in medicaments. Said amide derivatives the middle ply treated with a vascular endothelial mesenchymal stem cells specifically cells differentiation induction, and are by using an balloon expansion alcoholic beverage like damage for vascular endothelial cells, such as by a vascular event for the effective treatment is enabled.

Reaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H2 without oxidants and hydrogen acceptors

It is widely believed that the dehydrogenation of organic compounds is a thermodynamically unfavorable process, and thus requires stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. Here we report a previously unappreciated combination of common commercial Pd/C and H2 which dehydrogenates a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H2 as the only byproduct. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, we demonstrated it can be used as a cocatalyst to help power the reaction. This method for phenol synthesis manifests a high atom economy, and is inherently devoid of the complications normally associated with oxidative dehydrogenations.

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC BONE DISEASES CONTAINING ALPHA-ARYLMETHOXYACRYLATE DERIVATIVES

The present invention relates to a use of a specific alpha-arylmethoxyacrylate derivative, or its pharmacologically acceptable salt or solvate for preventing and treating metabolic bone diseases.

Palladium/proazaphosphatrane-catalyzed amination of aryl halides possessing a phenol, alcohol, acetanilide, amide or an enolizable ketone functional group: Efficacy of lithium bis(trimethylsilyl)amide as the base

A commercially available catalyst system comprising Pd(OAc)2 or Pd2(dba)3 and the proazaphosphatrane ancillary ligand P(i-BuNCH2CH2)3N (1) for the amination of aryl halides substituted with a phenol, alcohol, acetanilide, amide or ketone group containing an enolizable hydrogen is described. The reaction is performed in the presence of LiN(SiMe3)2 as the base. Other bases tested were either less effective or completely non-functional.