1618-56-0

Upstream product

• 38902-87-3 3-nitro-2,4-dichlorophenol 
• 74-88-4 methyl iodide 
• 56-93-9 benzyltrimethylammonium chloride 

Downstream Products

• 55285-43-3 2,6-dichloro-3-methoxyphenylamine 
• 1427407-32-6 N-(2,6-dichloro-3-methoxy-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide 
• 1427407-33-7 2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline 
• 1427407-34-8 2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol 
• 1427407-35-9 ethyl 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate 
• 1427406-18-5 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid 

Relevant academic research and scientific papers

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

Imidazole derivatives

Imidazole derivatives of the formula STR1 wherein R1, R2 and R3, independently, are hydrogen, halogen, trifluoromethyl, nitro, lower alkyl or lower alkylthio; one of R4 and R5 is hydrogen and the other is hydrogen, halogen, hydroxy or lower alkoxy; R6 is hydrogen or lower alkyl; R7 is hydrogen, hydroxy, lower alkyl or lower alkoxy; and either R8 is hydrogen, lower alkyl, lower alkenyl, aryl(lower alkyl) or acyl and R9 taken together with R is an additional bond, or R9 is lower alkyl, lower alkenyl or aryl(lower alkyl) and R8 taken together with R is an additional bond; provided that R4 or R5 is not hydroxy when R7 is lower alkoxy and/or R8 is acyl, and that R7 is not hydroxy when R4 or R5 is lower alkoxy and/or R8 is acyl, and their pharmaceutically acceptable acid addition salts are described, the compounds of formula I have valuable therapeutic properties and are especially useful as analgesics.