55285-43-3

Upstream product

• 1618-56-0 1,3-dichloro-4-methoxy-2-nitro-benzene 
• 7440-02-0 nickel 
• 38902-87-3 3-nitro-2,4-dichlorophenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 872509-55-2 2,6-dichloro-3-methoxyphenyl isocyanate 
• 82401-41-0 2,6-dichloro-3-methoxyphenylisothiocyanate 
• 1224639-54-6 N-(2,6-dichloro-3-methoxyphenyl)-2-(2,5-dichlorophenoxy)-5-fluoro-N-methylnicotinamide 
• 1427407-32-6 N-(2,6-dichloro-3-methoxy-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide 
• 1427407-33-7 2,6-dichloro-N-[[2-fluoro-5-(3-fluorophenyl)phenyl]methyl]-3-methoxyaniline 
• 1427407-34-8 2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol 
• 1427407-35-9 ethyl 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate 
• 1427406-18-5 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid 
• 1431873-07-2 C₁₈H₁₄Cl₂N₆O 
• 1618-62-8 2-(2,6-Dichloro-3-methoxy-phenylamino)-benzoic acid 

Relevant academic research and scientific papers

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl- piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase

A novel series of N-aryl-N′-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationally designing the substitution pattern of the aryl ring. On the b

PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS

The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

Imidazole derivatives

Imidazole derivatives of the formula STR1 wherein R1, R2 and R3, independently, are hydrogen, halogen, trifluoromethyl, nitro, lower alkyl or lower alkylthio; one of R4 and R5 is hydrogen and the other is hydrogen, halogen, hydroxy or lower alkoxy; R6 is hydrogen or lower alkyl; R7 is hydrogen, hydroxy, lower alkyl or lower alkoxy; and either R8 is hydrogen, lower alkyl, lower alkenyl, aryl(lower alkyl) or acyl and R9 taken together with R is an additional bond, or R9 is lower alkyl, lower alkenyl or aryl(lower alkyl) and R8 taken together with R is an additional bond; provided that R4 or R5 is not hydroxy when R7 is lower alkoxy and/or R8 is acyl, and that R7 is not hydroxy when R4 or R5 is lower alkoxy and/or R8 is acyl, and their pharmaceutically acceptable acid addition salts are described, the compounds of formula I have valuable therapeutic properties and are especially useful as analgesics.