161804-20-2

Basic information

• Product Name: BENZAMIL HYDROCHLORIDE
• Synonyms: Benzamil hydrate hydrochloride;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate;Benzamil hydrochloride hydrate;3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride
• CAS NO: 161804-20-2
• Molecular Formula: C13H14ClN7OHCl
• Molecular Weight: 0
• Mol File: 161804-20-2.mol

Chemical Properties

• Appearance: yellow/
• Storage Temp.: 2-8°C
• Solubility: methanol: soluble10mg/mL
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: BENZAMIL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZAMIL HYDROCHLORIDE(161804-20-2)
• EPA Substance Registry System: BENZAMIL HYDROCHLORIDE(161804-20-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 161804-20-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzamil Hydrochloride is used as a pharmacological agent for its potent inhibitory effects on the epithelial sodium channel, Na+/Ca2+ exchange transport, and the Na+/H+ antiporter. Its high potency (Ki = 10 nM vs 182 nM for Amiloride, IC50 = 9 μM for Na+/Ca2+ exchange transport, and IC50 = 80 nM for the Na+/H+ antiporter) makes it a valuable compound in the development of drugs targeting these transport mechanisms.
Used in Research Applications:
In the field of scientific research, Benzamil Hydrochloride serves as a valuable tool for studying the functions and roles of sodium channels, Na+/Ca2+ exchange transport, and Na+/H+ antiporters in various cellular processes. Its potent inhibitory properties allow researchers to investigate the underlying mechanisms and pathways involved in these transport systems, contributing to a better understanding of their biological significance and potential therapeutic applications.
Used in Drug Development:
Benzamil Hydrochloride's ability to inhibit key transport proteins makes it a promising candidate for the development of new drugs targeting various diseases and conditions. Its high potency and selectivity for specific transport systems can be leveraged to create targeted therapies with minimal side effects, potentially leading to more effective treatments for a range of medical conditions.

Biochem/physiol Actions

Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels

References

Cuthbert and Fanelli (1978), Effects of some pyrazinecarboxamides on sodium transport in frog skin; J. Pharmacol. 63 139 Kleyman and Cragoe (1988), Amiloride and Its Analogs as Tools in the Study of Ion Transport; Membrane Biol. 105 1