161805-78-3 Usage
Description
[(1S,2R)-1-(2-Chloro-acetyl)-2-methyl-butyl]-carbamic acid tert-butyl ester, commonly known as lomerizine, is a carbamic acid ester characterized by its molecular formula C14H24ClNO3. It is a calcium channel blocker with a specific stereochemistry that contributes to its pharmacological properties.
Uses
Used in Pharmaceutical Industry:
Lomerizine is used as a calcium channel blocker for the treatment of migraines and vertigo. It functions by blocking the influx of calcium ions into smooth muscle and cardiac muscle cells, which results in vasodilation and reduced excitability of these cells. This action helps alleviate symptoms such as headaches and dizziness associated with migraines and vertigo.
Used in Migraine Treatment:
In the treatment of migraines, lomerizine is used as an anti-headache agent. Its ability to block calcium channels helps to reduce the severity and frequency of migraine attacks by decreasing the constriction of blood vessels in the head and neck.
Used in Vertigo Treatment:
For vertigo treatment, lomerizine is used to reduce the sensation of dizziness and imbalance. By blocking calcium channels in the inner ear, it can help stabilize the balance system and minimize the symptoms of vertigo.
Safety Considerations:
As with all chemicals, lomerizine should be handled and used with care, adhering to safety guidelines to prevent potential hazards. Its use should be under the supervision of a healthcare professional to ensure proper dosage and to monitor for any adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 161805-78-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,8,0 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 161805-78:
(8*1)+(7*6)+(6*1)+(5*8)+(4*0)+(3*5)+(2*7)+(1*8)=133
133 % 10 = 3
So 161805-78-3 is a valid CAS Registry Number.
161805-78-3Relevant articles and documents
Ketomethylene and (cyanomethylene)amino pseudopeptide analogues of the C- terminal hexapeptide of neurotensin
Gonzalez-Muniz,Garcia-Lopez,Gomez-Monterrey,Herranz,Jimeno,Suarez-Gea,Johansen,Madsen,Thogersen,Suzdak
, p. 1015 - 1021 (2007/10/02)
A series of pseudopeptide analogues of the C-terminal hexapeptide of neurotensin (NT8-13), namely [Tyr11Ψ[COCH2]Phe12]-, [Ile12Ψ[COCH2]Phe13]-, and [Tyr11Ψ[CH(CN)NH]Il
