1618092-47-9

Upstream product

• 1312772-35-2 methyl [(2S)-1-(benzyloxy)-3-hydroxy-2-methylpropan-2-yl]carbamate 
• 1618092-39-9 (4R)-4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one 
• 1618092-42-4 {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 1618092-41-3 (4S)-4-(iodomethyl)-4-methyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1 agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.

Synthesis of a chiral phosphonium salt for the preparation of α-substituted alaninol derivatives

We herein report the synthesis of a chiral phosphonium salt, {[(4S)-4-methyl-2-oxo-1,3-oxazolidin-4-yl]methyl}(triphenyl)phosphonium iodide 13 to provide a new Wittig reagent for the general method of synthesizing α-substituted alaninol derivatives. Our method described here is widely applicable to reactions with various types of aldehyde to afford olefin products with high E-selectivity, enabling us to provide a new approach to the synthesis of chiral S1P1agonists including our key intermediates, and of the trace amine-associated receptor 1 (TAAR1) agonist.