16183-22-5Relevant academic research and scientific papers
Self-modulated highly chemoselective direct-reductive-amination (DRA) of benzaldehydes straightforward to N-monosubstituted benzylamine hydrochlorides
Xing, Lixin,Cheng, Chuanjie,Zhu, Rui,Zhang, Boyang,Wang, Xinyan,Hu, Yuefei
supporting information; experimental part, p. 11783 - 11788 (2009/04/05)
An unprecedented efficient and chemoselective DRA of benzaldehydes and primary amines was developed to directly yield N-monosubstituted benzylamine hydrochlorides as single products in practically quantitative yields. The method was characterized by simply adding a few milliliters of CHCl3 in the conventional Pd-C catalytic hydrogenation system at atmospheric pressure and room temperature. A self-modulated system and a four-stage cyclic pathway were proposed.
