16183-35-0Relevant academic research and scientific papers
SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
-
Page/Page column 215-216, (2012/12/13)
Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.
JOINT EFFECT OF STRUCTURAL FACTORS, TEMPERATURE, AND POLARITY OF THE MEDIUM ON RATE OF REACTIONS OF BENZYL BROMIDES WITH BUTYLAMINE. MANY-PARAMETER CORRELATIONS
Shpan'ko, I. V.,Serebryakov, I. M.,Korostylev, A. P.
, p. 1224 - 1230 (2007/10/02)
The rates of the reactions of benzyl bromides with butylamine were measured in nitrobenzene, chlorobenzene, and their mixtures at 40, 50, and 60 deg C and also in a 1:1 mixture of chlorobenzene with cyclohexane at 40 deg C.The effects of the variable factors (the structure of benzyl bromides, temperature, polarity of the medium) on the process rate were evaluated separately and in pairs and the joint effect of all three factors was also determined.The effect of the structure of the substrate and the polarity of the medium on the nature of the transition states in the reactions is discussed.
EFFECTS OF SUBSTITUENTS IN THE BENZYL BROMIDE ON THE KINETICS OF THE BENZYLATION OF AMINES
Shpan'ko, I. V.,Korostylev, A. P.,Rusu, L. N.
, p. 1715 - 1723 (2007/10/02)
The kinetics of the reactions of 3- and 4-substituted benzyl bromides with amines having various structures in nitrobenzene at 40 deg C were investigated.The 4-substituted benzyl bromides have higher reactivity compared with that calculated on the basis of the linear correlations according to the Hammett-Taft equation for unsubstituted and 3-substituted benzyl bromides containing electron-withdrawning substituents.The reactivity of benzyl bromides containing electron-donating substituents obeys a linear correlation with the ?+ constants.The effects of structural changes in the substrate and the nucleophile on the character of the transition states of the investigated reactions is discussed.
