161855-96-5Relevant articles and documents
Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems
Lin, Yang-I,Bitha, Panayota,Sakya, Subas M.,Li, Zhong,Lang Jr., Stanley A.,Yang, Youjun,Bhachech, Niraja,Weiss, William J.,Petersen, Peter J.,Jacobus, Nilda V.,Bush, Karen,Testa, Raymond T.
, p. 1665 - 1670 (2007/10/03)
Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.