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123-56-8 Usage

Chemical Properties

white crystalline powder

Definition

ChEBI: A dicarboximide that is pyrrolidine which is substituted by oxo groups at positions 2 and 5.

Purification Methods

Crystallise the imide from EtOH (1mL/g) or water. [Beilstein 21 H 369, 21/9 V 438.]
InChI:InChI=1/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)

123-56-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A13503)  Succinimide, 98+%    123-56-8 5000g 3544.0CNY Detail
Alfa Aesar (A13503)  Succinimide, 98+%    123-56-8 1000g 797.0CNY Detail
Alfa Aesar (A13503)  Succinimide, 98+%    123-56-8 250g 378.0CNY Detail

123-56-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name succinimide

1.2 Other means of identification

Product number -
Other names dihydromaleimide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-56-8 SDS

123-56-8Related news

Characterization of Succinimide (cas 123-56-8) stability during trypsin digestion for LC-MS analysis09/26/2019

LC-MS peptide mapping is the most commonly used method to analyze protein modifications. The proteins are generally digested using trypsin at a slightly basic pH at 37 °C from several hours to overnight. Assay-induced artifacts can be generated during this procedure, potentially causing false-p...detailed

Synthesis, antimicrobial activity and quantum chemical investigation of novel Succinimide (cas 123-56-8) derivatives09/24/2019

In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substit...detailed

Research ArticlePharmaceutical BiotechnologyCharacterization of Ring-Opening Reaction of Succinimide (cas 123-56-8) Linkers in ADCs09/10/2019

A new class of highly potent biopharmaceutical drugs, antibody-drug conjugates (ADCs), has been proven to be clinically effective to treat oncologic diseases. ADCs contain 3 major components: the monoclonal antibody, cytotoxic drug, and chemical linker. THIOMAB™ drug conjugates and interchain-cy...detailed

Characterization and quantification of Succinimide (cas 123-56-8) using peptide mapping under low-pH conditions and hydrophobic interaction chromatography09/09/2019

Characterization of asparagine deamidation and aspartic acid isomerization is an important aspect of biotherapeutic protein analysis due to the potential negative effect of these modifications on drug efficacy and stability. Succinimide has long been known to be an intermediate product of aspara...detailed

General CommentaryAn Automated and Qualified Platform Method for Site-Specific Succinimide (cas 123-56-8) and Deamidation Quantitation Using Low-pH Peptide Mapping09/08/2019

ABSTRACTMonoclonal antibodies undergo several post-translational modifications, including the formation of succinimide from the deamidation of asparagine or the isomerization of aspartic acid. Because of the potential impact of succinimide formation on the biological activity of monoclonal antib...detailed

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