123-56-8Relevant articles and documents
Unexpected Hydrogenation of C-C-Double Bonds with tert-Butyl Iodide
Jin, Shangde,Liebscher, Juergen
, p. 390 - 392 (1998)
Heating of 3-isobutylidene-2,5-diketopiperazines 1 or 4, maleinimide or 2,3-dichloro-5,6-dicyano-p-benzoquinone with tert-butyl iodide in toluene gave rise to hydrogenation of the conjugated C-C-double bond affording 3-isobutyldiketopiperazines 2(rac) and 3(rac), succinimide, or 2,3-dichloro-5,6-dicyanohydroquinone, respectively. Furthermore, an interesting N-O-migration of a benzoyl group as well as reductive aromatization to pyrazines 5 and 6, respectively, were observed.
Two-Bond Cleavage in the Oxidation of Acyclic Tertiary 1,4-Diols with N-Iodosuccinimide
Beebe, T. R.,Adkins, R. L.,Ng, F. W.,Weems, J. A.
, p. 3843 - 3845 (1984)
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Synthesis, characterization and cytotoxic studies of novel 1,2,4-triazole-azomethine conjugates
Mahar, Jamaluddin,Saeed, Aamer,Chaudhry, Gul-e-Saba,Irfan, Madiha,Channar, Pervaiz Ali,Faisal, Muhammad,Larik, Fayaz Ali
, p. 943 - 951 (2020)
Abstract: A series of 1,2,4-triazole-schiff hybrids were synthesized and characterized by mass spectrometry, FTIR and NMR spectroscopy. The compounds were screened for anticancer activity against human breast cancer cell line (MCF-7 and T47D) and human cervical cancer cell line (HeLa). The result indicates that newly synthesized compounds exhibit cytotoxicity to all cell lines studied. In particular, MCF-7 cells were shown to be more sensitive with EC50 50 13.10?μM/ml. To further investigate the mode of cell death, early and late apoptosis studies were done on MCF-7 cells. The externalization of phosphatidylserine and DNA fragmentation supports the apoptosis as the major mode of cell death induced by derivatives on MCF-7 cells. Graphic abstract: [Figure not available: see fulltext.]
One-Electron Reduction Potential and Ring Opening of the Succinimidyl Radical in Water
Lind, Johan,Jonsson, Mats,Eriksen, Trygve E.,Merenyi, Gabor,Eberson, Lennart
, p. 1610 - 1614 (1993)
By means of pulse radiolysis in water, N-chlorosuccinimide (SCl) was reduced in a one-electron step to yield the succinimidyl radicals, S*, via the intermediacy of the radical anion, SCl*-.The rate of ring opening of S* was measured to be 8 x 104 s-1.By equilibrium with Cl2*-/2Cl-, the one-electron reduction potential of S* was determined to be 2.22 +/- 0.02 V vs NHE.From this value and other data, the N-H bond strength in succinimide was calculated to be 118 +/- 3 kcal/mol.
Polarographic determination of vitamin C after derivatization with o-phenylenediamine
Rodrigues, Jose Antonio,Valente, Ines Maria,Goncalves, Luis Moreira,Pacheco, Joao Grosso,Barros, Aquiles Araujo
, p. 731 - 741 (2010)
A differential pulse polarographic (DPP) method has been developed for the determination of ascorbic acid (AA) and dehydroascorbic acid (DHA), the two main forms of Vitamin C. The method consists of the DPP analysis of a quinoxaline obtained by the derivatization of DHA with o-phenylenediamine. Results using the proposed method correlated well with those obtained by two reference methodologies: the common iodometric method and a published chromatographic methodology. It was also used in the study of Vitamin C degradation in fruit juices, showing that it involves an initial oxidation of AA to DHA, followed by ydrolytic degradation of the latter.
Mechanism of Photoredox-Initiated C-C and C-N Bond Formation by Arylation of IPrAu(I)-CF3 and IPrAu(I)-Succinimide
Kim, Suhong,Toste, F. Dean
, p. 4308 - 4315 (2019)
Herein, we report on the photoredox-initiated gold-mediated C(sp2)-CF3 and C(sp2)-N coupling reactions. By adopting gold as a platform for probing metallaphotoredox catalysis, we demonstrate that cationic gold(III) complexes are the key intermediates of the C-C and C-N coupling reactions. The high-valent gold(III) intermediates are accessed by virtue of photoredox catalysis through a radical chain process. In addition, the bond-forming step of the coupling reactions is the reductive elimination from cationic gold(III) intermediates, which is supported by isolation and crystallographic characterization of key Au(III) intermediates.
Synthesis of biobased succinimide from glutamic acid via silver-catalyzed decarboxylation
Deng, Jin,Zhang, Qiu-Ge,Pan, Tao,Xu, Qing,Guo, Qing-Xiang,Fu, Yao
, p. 27541 - 27544 (2014)
Glutamic acid was transformed into succinimide in a two step procedure involving a dehydration in water to pyroglutamic acid followed by an oxidative decarboxylation using a silver catalyst.
Reply to the Correspondence on “Preorganization and Cooperation for Highly Efficient and Reversible Capture of Low-Concentration CO2 by Ionic Liquids”
Huang, Yanjie,Cui, Guokai,Zhao, Yuling,Wang, Huiyong,Li, Zhiyong,Dai, Sheng,Wang, Jianji
, p. 386 - 389 (2019)
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N -Iodosuccinimide-Promoted Selective Construction of Cyclopropyl and Dihydrofuranyl Spirooxindoles from Alkylidene Oxindoles and Annular β-Dicarbonyl Compounds
Chen, Hong,He, Zeng-Yang,Huang, Fei-Hong,Jin, Ying,Xu, Hui,Zhang, Ze,Zou, Peng
supporting information, (2022/03/08)
An efficient N-iodosuccinimide-promoted cyclization of readily available alkylidene oxindoles with annular β-dicarbonyl compounds has been demonstrated. With five-membered cyclic β-dicarbonyl compounds as the starting materials, a series of cyclopropyl oxindoles can be obtained in good to excellent yields, whereas the method affords dihydrofuranyl spirooxindoles almost quantitatively when six- or seven-membered cyclic β-dicarbonyl compounds are employed. This protocol provides a new alternative to the practical synthesis of structurally diverse spirooxindoles.
Generalized Chemoselective Transfer Hydrogenation/Hydrodeuteration
Wang, Yong,Cao, Xinyi,Zhao, Leyao,Pi, Chao,Ji, Jingfei,Cui, Xiuling,Wu, Yangjie
supporting information, p. 4119 - 4129 (2020/08/10)
A generalized, simple and efficient transfer hydrogenation of unsaturated bonds has been developed using HBPin and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, are all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H2 combination, are tolerated. The activity of the reactants was studied and the trends are as follows: styrene'diphenylmethanimine'benzaldehyde'azobenzene'nitrobenzene'quinoline'acetophenone'benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalyst in situ generated from Pd(OAc)2 and HBPin extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBPin via in situ HD generation and discrimination. (Figure presented.).
Method for preparing diloxitol fumarate
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Paragraph 0072-0074; 0081-0083; 0088-0090; 0095-0097, (2020/02/14)
The invention relates to the technical field of a bulk drug preparation method and in particular relates to a method for preparing a bulk drug diloxitol fumarate. The preparation method comprises thefollowing steps: 1) performing an ammoniation reaction, namely enabling succinic anhydride to react with an ammoniating reagent so as to produce succinimide; 2) performing an alkylation reaction, namely enabling succinimide to react with 1,2 halogenated ethane in the presence of a catalyst and a base so as to generate a compound of a formula IV shown in the description; and 3) performing an esterification reaction, namely enabling a compound of a formula IV compound shown in the description to react with trans-monomethyl fumarate, so as to generate diloxifyl fumarate. The method has the advantages that material reagents used in the method are convenient and easy to obtain, the reaction steps are short, the total yield is high, the product is easy to purify through recrystallization, and base toxic impurities are easy to be controlled through recrystallization, and the like.