1618672-85-7Relevant academic research and scientific papers
BF3·OEt2-catalyzed synthesis of 1-(tetrahydropyran-3-yl)-1,3-dihydroisobenzofuran and trans-fused hexahydropyrano[3,2-c]chromene derivatives
Syama Sundar,Ramana Reddy,Sridhar,Kiran Kumar,Suresh Reddy,Reddy, B.V. Subba
, p. 4236 - 4239 (2014)
A novel intramolecular Prins cyclization of (E)-5-(2-(hydroxymethyl)phenyl) pent-4-en-1-ol with aldehydes has been achieved using 10 mol % BF 3·Et2O to produce 1-(tetrahydropyran-3-yl)-1,3- dihydroisobenzofuran derivatives in good to excellent yields with high selectivity. Similar type of coupling with salicylaldehydes provides the trans-fused hexahydropyrano[3,2-c]chromene derivatives in excellent yields.
