1618673-08-7Relevant academic research and scientific papers
Tertiary amide-based Knoevenagel-type reactions: A direct, general, and chemoselective approach to enaminones
Huang, Pei-Qiang,Ou, Wei,Xiao, Kai-Jiong,Wang, Ai-E.
supporting information, p. 8761 - 8763 (2014/07/22)
We report one-pot and chemoselective Knoevenagel-type reactions using highly stable amides and lactams as the electrophilic substrates. The method is based on the in situ activation of amide carbonyl with triflic anhydride and a subsequent reaction with carbanions generated in situ from carbonyl compounds. The amide-based method is an alternative to the versatile thioamide-based Eschenmoser sulfide contraction.
