1618698-49-9

Upstream product

• 869857-92-1 (2S,3S,4R,5S)-1-benzyloxycarbonyl-2-formyl-5-methylpyrrolidine-3,4-diol 
• 1618698-48-8 (2S,3S,4R,5S)-2-hydroxymethyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 
• 501-53-1 benzyl chloroformate 
• 1618698-45-5 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-O-methanesulfonyl-D-lyxononitrile 

Downstream Products

• 1632125-06-4 C₃₁H₄₈N₄O₄ 
• 1632125-07-5 C₂₈H₄₄N₄O₄ 
• 1632124-94-7 (2S,3S,4R,5S)-N-benzyloxycarbonyl-2-tosyloxymethyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 
• 1618698-58-0 (2S,3R,4S,5S)-2-methyl-5-[(4-phenyl-1H-1,2,3-triazol-1-yl)methyl]pyrrolidine-3,4-diol 
• 1618698-56-8 C₂₅H₂₈N₄O₄ 
• 1618698-57-9 C₂₂H₂₄N₄O₄ 
• 1618698-52-4 (2S,3S,4R,5S)-N-benzyloxycarbonyl-2-azidomethyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 

Relevant academic research and scientific papers

Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles

The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The in situ screening for the activity towards α-fucosidase of the resulting triazoles has allowed the identification of one of the most potent and selective pyrrolidine derived inhibitors of this enzyme (Ki = 4 nM). This journal is the Partner Organisations 2014.

Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives

A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for their ability to inhibit the growth of pancreatic ductal adenocarcinoma cells in vitro. The new compounds are shown to exhibit anticancer activity at concentrations in the μM range. ARKAT-USA, Inc.