1618698-45-5

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1618698-54-6 (2S,3S,4R,5S)-2-(1-benzyl-1H-1,2,3-triazol-4-yl)-5-methyl-pyrrolidine-3,4-diol 
• 1618698-58-0 (2S,3R,4S,5S)-2-methyl-5-[(4-phenyl-1H-1,2,3-triazol-1-yl)methyl]pyrrolidine-3,4-diol 
• 1618698-53-5 C₂₂H₃₀N₄O₄ 
• 1618698-56-8 C₂₅H₂₈N₄O₄ 
• 1618698-57-9 C₂₂H₂₄N₄O₄ 
• 1618698-61-5 C₁₅H₂₀N₄O₃ 
• 1618698-64-8 C₁₅H₂₀N₄O₂ 
• 1618698-65-9 C₁₄H₁₈N₄O₂S 
• 1618698-66-0 C₁₄H₂₄N₄O₂ 
• 1618698-75-1 (2S,3S,4R,5S)-2-[1-((4-benzyloxycarbonyl-5-methylfuran-2-yl)-methyl)-1H-1,2,3-triazol-4-yl]-5-methylpyrrolidine-3,4-diol 
• 1618698-76-2 C₂₂H₂₆N₄O₆ 
• 1618698-77-3 C₂₂H₂₆N₄O₆ 
• 1618698-78-4 C₂₄H₃₀N₄O₈ 
• 1618698-49-9 (2S,3S,4R,5S)-N-benzyloxycarbonyl-2-hydroxymethyl-3,4-O-isopropyliden-5-methylpyrrolidine-3,4-diol 

Relevant academic research and scientific papers

Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles

The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The in situ screening for the activity towards α-fucosidase of the resulting triazoles has allowed the identification of one of the most potent and selective pyrrolidine derived inhibitors of this enzyme (Ki = 4 nM). This journal is the Partner Organisations 2014.