1618698-76-2

Upstream product

• 1618698-55-7 (2S,3S,4R,5S)-2-ethynyl-5-methylpyrrolidine-3,4-diol 
• 1618698-48-8 (2S,3S,4R,5S)-2-hydroxymethyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 
• 1618698-50-2 (2S,3S,4R,5S)-N-tert-butoxycarbonyl-2-hydroxymethyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 
• 1449248-48-9 (2R,3S,4R,5S)-N-tert-butoxycarbonyl-2-formyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 
• 608-46-8 α-D-lyxopyranose 
• 1618698-45-5 5-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-4-O-methanesulfonyl-D-lyxononitrile 
• 1618698-51-3 (2S,3S,4R,5S)-N-tert-butoxycarbonyl-2-ethynyl-3,4-O-isopropylidene-5-methylpyrrolidine-3,4-diol 

Relevant academic research and scientific papers

Rapid discovery of potent α-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles

The synthesis of a small library of (pyrrolidin-2-yl)triazoles via copper catalysed cycloaddition of an alkynyl iminocyclopentitol and a set of commercial and synthetic azides has been achieved. The in situ screening for the activity towards α-fucosidase of the resulting triazoles has allowed the identification of one of the most potent and selective pyrrolidine derived inhibitors of this enzyme (Ki = 4 nM). This journal is the Partner Organisations 2014.